腹腔镜下超声刀手术联合化疗治疗宫颈癌患者的临床疗效及对炎性因子的影响  

Clinical Effectiveness and Inflammatory Factors of Cervical Carcinoma Patients Using the Laparoscopic Ultrasonic Scalpel Surgery and Chemotherapy

作　　者：李雪 周新欢[1] 张倩 LI Xue;ZHOU Xinhuan;ZHANG Qian(Department of Gynecology Special Needs Area 2,Nanyang Central Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市中心医院妇科特需二病区,河南南阳473000

出　　处：《临床研究》2023年第5期28-31,共4页Clinical Research

摘　　要：目的分析对宫颈癌患者实施腹腔镜下超声刀手术联合化疗的疗效及对炎性因子的影响。方法将南阳市中心医院2020年9月至2022年9月就诊的102例宫颈癌患者作为研究对象,依托区间随机法开展1∶1组别划分,对照组单纯接受腹腔镜下超声刀手术治疗,实验组在腹腔镜下超声刀手术前开展化疗。比较两组治疗前后癌症患者生命质量评分(FACT-G)、宫颈癌肿瘤标志物水平及炎性因子指标变化情况。结果治疗前,组间癌症患者生命质量评分对比,差异无统计学意义(P>0.05);治疗后,实验组各维度评分高于对照组,差异有统计学意义(P<0.05)。治疗前,两组肿瘤标志物水平对比,差异无统计学意义(P>0.05);治疗后,实验组癌胚抗原(CEA)、糖链抗原19、糖链抗原19-9(CA19-9)、细胞角蛋白19片段21-1(CYFRA21-1)水平均低于对照组,差异有统计学意义(P<0.05)。治疗前,组间各炎性因子水平对比,差异无统计学意义(P>0.05);治疗后,实验组C反应蛋白、降钙素原、肿瘤坏死因子α、白介素-6水平低于对照组,差异有统计学意义(P<0.05)。结论腹腔镜下超声刀手术联合化疗治疗宫颈癌可改善患者生活质量,显著降低肿瘤标志物水平,且能明显降低机体炎性因子水平,值得临床应用。Objective To analyze the clinical effectiveness and inflammatory factors of cervical carcinoma patients using the laparoscopic ultrasonic scalpel surgery and chemotherapy.Methods A total of 102 cervical carcinoma patients treated from September 2020 to September 2022 in Nanyang Central Hospital were chosen as research subjects.According to random interval method,patients were divided into control group(N=51,laparoscopic ultrasonic scalpel surgery)and test group(N=51,laparoscopic ultrasonic scalpel surgery and chemotherapy).Functional assessment of cancer therapy general(FACT-G)scores,tumor markers and inflammatory factors were compared between two groups before and after treatment.Results Before therapy,FACT-G scores between groups were not significantly different(P>0.05);After treatment,the scores in each dimension of test group were higher than those of the control group,which were statistically significant(P<0.05);Before therapy,the tumor markers between groups were not significantly different(P>0.05);After therapy,the carcino-embryonic antigen(CEA),carbohydrate antigen 19,carbohydrate antigen 19-9(CA19-9)and cytokeratin 19 fragment 21-1(CYFRA21-1)levels in the test group were significantly lower than those in the control group,with significant differences(P<0.05);Before therapy,the inflammatory factors between groups were not significantly different(P>0.05);After therapy,C-reactive protein,procalcitonin,tumor necrosis factor-αand Interleukin-6 levels in the test group were significantly lower than those in the control group,with significant differences(P<0.05).Conclusion The laparoscopic ultrasonic scalpel surgery and chemotherapy for cervical cancer can improve the quality of life of patients,significantly reduce the level of tumor markers,and significantly reduce the level of inflammatory factors,which is worthy of clinical application.

关 键 词：宫颈癌 腹腔镜下超声刀手术 化疗 炎性因子 

分 类 号：R737.33[医药卫生—肿瘤]