β阻滞剂联合碳酸酐酶抑制剂对新生血管性青光眼术后眼压及细胞因子的影响  

The Influence ofβ-blocker and Carbonic Anhydrase Inhibitors on the Postoperative Intraocular Pressure and Cell Factors for Neovascular Glaucoma Patients

作　　者：杨静雅 YANG Jingya(Department of Ophthalmology,Nanyang Central Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市中心医院眼科,河南南阳473000

出　　处：《临床研究》2023年第5期79-82,共4页Clinical Research

摘　　要：目的研讨新生血管性青光眼术后应用β阻滞剂、碳酸酐酶抑制剂治疗对眼压、细胞因子的影响。方法选择南阳市中心医院2021年6月至2022年6月收治的96例新生血管性青光眼患者,按随机数字表法分成两组,各48例(50眼)。对照组给予单一β阻滞剂治疗,观察组给予β阻滞剂、碳酸酐酶抑制剂治疗,比较两组临床疗效、眼压和细胞因子。结果观察组治疗有效率(96.00%)高于对照组(84.00%),差异有统计学意义(P<0.05)。观察组眼压峰值下降值、随机眼压下降值和24 h眼压下降值均大于对照组,24 h眼压波动值小于对照组,差异有统计学意义(P<0.05)。治疗前,两组血清及房水色素上皮衍生因子(PEDF)、血管内皮生长因子(VEGF)、白细胞介素-6(IL-6)值比较,差异无统计学意义(P>0.05);治疗后,血清PEDF和房水PEDF值高于对照组,血清和房水VEGF、IL-6值均低于对照组,差异有统计学意义(P<0.05)。结论新生血管性青光眼术后采用β阻滞剂联合碳酸酐酶抑制剂疗效显著,能降低眼压水平,对细胞因子的合成进行调节。Objective To discuss the influence ofβ-blocker and carbonic anhydrase inhibitors on the postoperative intraocular pressure and cell factors for neovascular glaucoma patients.Methods A total of 96 neovascular glaucoma patients treated from June 2021 to June 2022 in Nanyang Central Hospital were selected as subjects.According to random number table,patients were divided into control group(48 cases,50 eyes)and observation group(48 cases,50 eyes).A singleβ-blocker was applied in the control group;β-blocker and carbonic anhydrase inhibitors were applied in the observation group.The clinical effects,intraocular pressure and cell factors were compared between two groups.Results The total effective treatment rate in the observation group(95.83%)was significantly higher than control group(83.33%),with significant difference(P<0.05);The descent degrees of peak intraocular pressure,random intraocular pressure and 24-hour intraocular pressure in the observation group were higher than control group,the fluctuation degrees of 24-hour intraocular pressure in the observation group was lower than control group,with significant differences (P < 0.05);Before treatment, there were no significant between-group differences about the serumand aqueous fluid pigment epithelium-derived factor (PEDF), vascular endothelial growth factor (VEGF) and Interleukin-6 (IL-6) levels (P > 0.05);After treatment, serum and aqueous fluid PEDF levels in the observation group were higher than controlgroup;serum and aqueous fluid VEGF and IL-6 levels were lower than control group, with significant differences (P < 0.05).Conclusion β-blocker and carbonic anhydrase inhibitors can effectively reduce the postoperative intraocular pressure and adjustthe cell factors for neovascular glaucoma patients.

关 键 词：碳酸酐酶抑制剂 新生血管性青光眼 Β阻滞剂 眼压 细胞因子 

分 类 号：R770[医药卫生—眼科]