雷贝拉唑联合法莫替丁对Hp阳性消化性溃疡并出血患者的疗效及对VEGF、IL-6水平的影响  

Efficacy of Rabeprazole Combined with Famotidine in Patients with Hp Positive Peptic Ulcer Complicated with Bleeding and Its Effect on VEGF and IL-6 Levels

作　　者：赵帅[1] 常振东[1] 姜君 ZHAO Shuai;CHANG Zhendong;JIANG Jun(Department of Emergency Medicine,Nanyang Central Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市中心医院急诊内科,河南南阳473000

出　　处：《临床研究》2023年第5期89-92,共4页Clinical Research

摘　　要：目的探讨雷贝拉唑联合法莫替丁对幽门螺杆菌(Hp)阳性消化性溃疡病并出血患者的疗效及对血管内皮生长因子(VEGF)、白细胞介素-6(IL-6)水平的影响。方法选取2021年1月至2022年1月南阳市中心医院收治的80例Hp阳性消化性溃疡并出血患者为研究对象,按照数字表法随机将其分为观察组和对照组,每组各40例。对照组给予法莫替丁治疗,观察组给予雷贝拉唑联合法莫替丁治疗。对比两组疗效、出血停止时间、住院时间、治疗前后VEGF、IL-6水平、不良反应发生率、Hp根除率、Hp再感染率。结果观察组临床有效率(92.50%)高于对照组(75.00%),差异有统计学意义(P<0.05)。观察组患者出血停止时间和住院时间均短于对照组,差异有统计学意义(P<0.05)。两组患者治疗后VEGF水平高于治疗前,且观察组高于对照组;两组IL-6水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率(25.00%)、Hp根除率(90.00%)、Hp再感染率(5.00%)与对照组(17.50%、85.00%、7.50%)比较差异无统计学意义(P>0.05)。结论Hp阳性消化性溃疡病并出血患者采用雷贝拉唑联合法莫替丁治疗,其疗效较佳,可缩短患者康复时间,改善VEGF、IL-6水平,且安全性较好。Objective To investigate the efficacy of rabeprazole combined with famotidine on Helicobacter pylori(Hp)positive peptic ulcer disease complicated with bleeding and its effect on vascular endothelial growth factor(VEGF)and interleukin-6(IL-6)levels.Methods Selected 80 patients with Hp-positive peptic ulcer and bleeding who were treated in our hospital from January 2021 to January 2022 as the research objects,and randomly divided them into the observation group and the control group according to the digital table method,with 40 cases in each group and the control group.The control group was given famotidine treatment,and the observation group was given rabeprazole combined with famotidine treatment.The curative effect,bleeding stop time,hospital stay,VEGF and IL-6 levels before and after treatment,incidence of adverse reactions,Hp eradication rate,and Hp reinfection rate were compared between the two groups.Results The total effective rate of the observation group was 92.50%higher than that of the control group 75.00%,the difference is statistically significant(P<0.05);the bleeding stop time and hospitalization time in the observation group were shorter than those in the control group,the difference is statistically significant(P<0.05);after treatment,the VEGF level in the two groups was higher than before treatment,the observation group was higher than the control group,the IL-6 level was lower than before treatment,and the observation group was lower than the control group,the difference is statistically significant(P<0.05);there were no significant differences in the incidence of adverse reactions(25.00%),Hp eradication rate(90.00%)and Hp reinfection rate(5.00%)between the observation group and the control group(17.50%,85.00%,7.50%)(P>0.05).Conclusion Patients with Hp-positive peptic ulcer disease with bleeding were treated with rabeprazole in combination with famotidine,which had better efficacy,shortened recovery time,improved VEGF and IL-6 levels,and with better security.

关 键 词：消化性溃疡 幽门螺杆菌 出血 雷贝拉唑 法莫替丁 

分 类 号：R573[医药卫生—消化系统]