舒血宁注射液对帕金森病患者临床疗效、脑区血流量及炎性因子的影响  

Effect of Shuxuening Injection onClinical Efficacy,Cerebral Blood Flow and Inflammatory Factors in Patients with Parkinson’s Disease

作　　者：冯慧 李珂[2] 尚金花 FENG Hui;LI Ke;SHANG Jinhua(Encephalopathy Department,Traditional Chinese Medicine Hospital of Anyang County,Anyang Henan 455100,China;Department of Neurology,Anyang Regional Hospital of Puyang City,Anyang Henan 455000,China;Department of Neurology,Traditional Chinese Medicine Hospital of Anyang County,Anyang Henan 455100,China)

机构地区：[1]安阳县中医院脑病科,河南安阳455100 [2]濮阳市安阳地区医院,神经内科,河南安阳455000 [3]安阳县中医院神经内科,河南安阳455100

出　　处：《临床研究》2023年第5期103-105,共3页Clinical Research

摘　　要：目的探讨舒血宁注射液对帕金森病患者临床疗效、脑区血流量及炎性因子的影响。方法选取安阳县中医院2020年1月至2022年10月收治的96例帕金森病患者,按随机数字表法分为对照组(N=48)和观察组(N=48)。观察组患者予以多巴丝肼联合舒血宁治疗,对照组单独予以多巴丝肼。比较两组患者症状评分、临床疗效、脑区血流量、炎性因子及不良反应情况。结果两组治疗后1个月及4个月,患者症状评分均降低,且观察组均低于对照组,差异有统计学意义(P<0.05)。两组患者疗效相比,观察组优于对照组,差异有统计学意义(P<0.05)。两组脑区血流量均较治疗前显著增加,且观察组增加幅度大于对照组,差异有统计学意义(P<0.05)。两组血清炎性因子水平较治疗前均降低,且观察组低于对照组(P<0.05)。两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论舒血宁注射液可改善帕金森病患者脑区血流量及临床症状,显著降低炎症水平,疗效较优且不会增加不良反应。Objective To investigate the effect of Shuxuening injection on clinical efficacy,cerebral blood flow and inflammatory factors in patients with Parkinson’s disease.Methods A total of 96 patients with Parkinson's disease admitted to our hospital from January 2020 to October 2022 were selected and divided into the control group(N=48)and the observation group(N=48)according to the random number table method.Patients in the watched group were treated with dobutamine combined with sulforaphane,while the matched group was treated with dobutamine alone.Cerebral blood flow,efficacy,symptom scores,inflammatory factors,and adverse effects were compared between the two groups.Results At 1 month and 4 months after treatment,the symptom scores decreased in both groups,and were lower in the watched group compared with both groups,the difference is statistically significant(P<0.05);the efficacy was better in the watched group compared with both groups,the difference is statistically significant(P<0.05);the cerebral blood flow increased significantly in both groups compared with that before treatment,and the increase was greater in the watched group,the difference is statistically significant(P<0.05);the serum inflammatory factor levels decreased in both groups,and were lower in the watched group compared with both groups(P<0.05);there was no statistical difference in the incidence of adverse reactions between the two groups compared with each other(P>0.05).Conclusion ShuXueNing injection can improve blood flow and clinical symptoms in the cerebral area of patients with Parkinson’s disease,improve the treatment effect of patients,reduce the inflammatory response of patients,and do not increase the adverse reactions.

关 键 词：帕金森 脑区血流量 舒血宁注射液 临床症状 

分 类 号：R742.5[医药卫生—神经病学与精神病学]