肠道真菌失调和消化系肿瘤关系的研究进展  

Progress in the relationship between intestinal fungal dysbiosis and digestive system tumors

作　　者：张宸已 房静远[1] Zhang Chenyi;Fang Jingyuan(Division of Gastroenterology and Hepatology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Institute of Digestive Disease,Shanghai 200001,China)

机构地区：[1]上海交通大学医学院附属仁济医院消化科,上海市消化疾病研究所,上海200001

出　　处：《中华微生物学和免疫学杂志》2023年第3期243-247,共5页Chinese Journal of Microbiology and Immunology

摘　　要：肠道真菌失调与多种疾病如肿瘤等的发生及发展息息相关,真菌失调会通过引发异常的宿主免疫应答、产生特定代谢产物以及与细菌的相互作用等多种途径参与肿瘤的发生及发展,并具备作为标志物预警消化系肿瘤、影响消化系肿瘤治疗效果等潜能。对肠道真菌和消化系肿瘤之间联系的探究或有助于消化系肿瘤的预防、诊断及治疗。Intestinal fungal dysbiosis is closely associated with the development and progression of many diseases including tumors.The disruption of fungal communities is involved in tumorigenesis and progression through inducing aberrant host immune responses and the production of certain metabolites as well as promoting the establishment of interactions with bacteria.Fungal dysbiosis is a potential marker for early detection of digestive tumors and a factor influencing the efficacy of tumor therapy.Studying the association between gut fungi and digestive tumors may facilitate the prevention,diagnosis and treatment of digestive tumors.

关 键 词：真菌失调 消化系肿瘤 肿瘤发生及发展 治疗 

分 类 号：R735[医药卫生—肿瘤]