孤独症谱系障碍男童感觉运动网络最优频率异常发育模式  

Atypical developmental of the sensorimotor network optimal frequency in children with autism spectrum disorder

作　　者：卢春赢 张浅阅 陈雪 李博文 贺碧芳 叶绍兵 陈恒 LU Chunying;ZHANG Qianyue;CHEN Xue;LI Bowen;HE Bifang;YE Shaobing;CHEN Heng(School of Medicine,Guizhou University,Guiyang(550025),China;不详)

机构地区：[1]贵州大学医学院,贵阳550025 [2]重庆市开州区人民医院普通外科

出　　处：《中国学校卫生》2023年第3期344-347,共4页Chinese Journal of School Health

基　　金：国家自然科学基金(61901129,61901130);贵州省科技厅科学技术基金一般项目([2020]1Y345)。

摘　　要：目的基于功能连接优势频率指标,采用“脑年龄”分析方法,探索孤独症谱系障碍(autism spectrum disorder,ASD)男童感觉运动相关网络的异常发育模式。方法筛选来自ABIDE数据库中105例ASD男童与匹配的102例正常发育男童的静息态功能磁共振数据(7~12岁)。每个被试构建感觉运动相关脑区不同频段下的功能连接网络,然后计算每条连接最强连接值所在的频率作为该连接的最优频率。采用脑年龄分析方法探索ASD男童脑年龄相对于生理年龄的年龄差。结果ASD男童大脑感觉运动网络出现“过发育”到“欠发育”的异常发育模式,2种模式的转换在7.8岁左右。“欠发育”趋势得到抑制的大龄ASD男童(10岁以上)病情严重程度相对更轻(r=-0.43,P<0.05)。结论ASD男童大脑感觉运动网络存在异常发育过程,感觉运动网络脑-生理年龄差有作为衡量ASD疾病发展过程的神经影像学标记物潜力。Objective On the basis of the dominant frequency index of functional connectivity,the"brain age"analysis method was used to explore abnormal development patterns of sensorimotor networks in boys with autism spectrum disorder(ASD).Methods The resting state functional magnetic resonance data(7-12 years old)for 105 boys with ASD and 102 matched boys with normal development from the ABIDE public database were screened.Functional connection networks in different frequency bands of sensorimotor related brain regions were constructed for each individual,and the frequency of the strongest connection were constructed as the optimal frequency of the connection.Brain age analysis was used to explore the difference between brain age and chronological age in boys with ASD.Results The brain sensorimotor network of boys with ASD showed an abnormal development pattern of overdevelopment followed by underdevelopment,and the transition between the two patterns occurred at approximately 7.8 years of age.Older boys with ASD(older than 10 years)whose underdevelopment trend was suppressed had lower ASD severity(r=-0.43,P<0.05).Conclusion The brain sensorimotor network in boys with ASD has an abnormal development process,and the brain-chronological age difference in the sensorimotor network has potential as a neuroimaging marker to measure the development of ASD.

关 键 词：孤独性障碍 感觉 运动活动 生长和发育 儿童 男(雄)性 

分 类 号：R748[医药卫生—神经病学与精神病学] R179[医药卫生—临床医学]