烷基链结构对吐温表面活性剂包载姜黄素的影响  

Effect of Alkyl Chain Structure on the Encapsulation of Curcumin by Tween Surfactants

作　　者：郑雨晴 王小永[1] ZHENG Yuqing;WANG Xiaoyong(School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China)

机构地区：[1]华东理工大学化学与分子工程学院,上海200237

出　　处：《华东理工大学学报（自然科学版）》2023年第2期188-195,共8页Journal of East China University of Science and Technology

基　　金：国家自然科学基金(21573071,22273022)。

摘　　要：姜黄素在3种吐温聚集体中的稳定性和结合常数的大小顺序为:吐温-85囊泡>吐温60囊泡>吐温-80胶束。紫外吸收光谱和荧光发射光谱测定结果表明姜黄素以疏水作用为主要驱动力包载于吐温聚集体的烷基链疏水区域。核磁共振氢谱测定结果表明姜黄素的包载位置和作用力与吐温的烷基链结构有密切关系。相比粒径约为92 nm的吐温-60囊泡,烷基链中含有双键的吐温-80的疏水区域生成了具有疏松排列结构的吐温-80胶束,这使得姜黄素表现出较低的稳定性、结合常数,以及紫外吸收强度和荧光发射强度。带有3条不饱和烷基链的吐温85能够生成粒径约为150 nm的囊泡,其双分子层具有最高疏水性,因此其对姜黄素有最好的包载效果。The order of the stability and binding constant of curcumin encapsulated by three Tween aggregates is:Tween-85 vesicles>Tween-60 vesicles>Tween-80 micelles.Upon UV and fluorescence measurements,it is found that curcumin is encapsulated in the hydrophobic region of the alkyl chains of Tween aggregates driven by hydrophobic interaction.The 1H-NMR data confirm that the encapsulation position and force of curcumin are closely related to the alkyl chain structure of Tween surfactants.Compared with Tween-60 vesicles with a particle size of about 92 nm,the micelles formed by Tween-80 containing double bonds in the alkyl chain have loosely arranged hydrophobic region.Therefore,curcumin encapsulated by Tween-80 micelles exhibits lower stability,binding constant,UV absorption and fluorescence emission intensities.Tween-85 with three unsaturated alkyl chains can generate vesicles with a particle size of about 150 nm,and its bilayer has the highest hydrophobicity which shows the best encapsulation effect on curcumin.

关 键 词：吐温表面活性剂 姜黄素 双键 囊泡 疏水作用 

分 类 号：O648[理学—物理化学]