Wound microenvironment self-adaptive hydrogel with efficient angiogenesis for promoting diabetic wound healing  

作　　者：Zijian Shao Tianyu Yin Jinbo Jiang Yang He Tao Xiang Shaobing Zhou 

机构地区：[1]Key Laboratory of Advanced Technologies of Materials,Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu,610031,PR China

出　　处：《Bioactive Materials》2023年第2期561-573,共13页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(Nos.52103186,51725303,52033007);the Fundamental Research Funds for the Central Universities(Nos.2682020ZT84,2682021ZTPY008).

摘　　要：Neovascularization is critical to improve the diabetic microenvironment,deliver abundant nutrients to the wound and promote wound closure.However,the excess of oxidative stress impedes the healing process.Herein,a self-adaptive multifunctional hydrogel with self-healing property and injectability is fabricated through a boronic ester-based reaction between the phenylboronic acid groups of the 3-carboxyl-4-fluorophenylboronic acid-grafted quaternized chitosan and the hydroxyl groups of the polyvinyl alcohol,in which pro-angiogenic drug of desferrioxamine(DFO)is loaded in the form of gelatin microspheres(DFO@G).The boronic ester bonds of the hydrogel can self-adaptively react with hyperglycemic and hydrogen peroxide to alleviate oxidative stress and release DFO@G in the early phase of wound healing.A sustained release of DFO is then realized by responding to overexpressed matrix metalloproteinases.In a full-thickness diabetic wound model,the DFO@G loaded hydrogel accelerates angiogenesis by upregulating expression of hypoxia-inducible factor-1 and angiogenic growth factors,resulting in collagen deposition and rapid wound closure.This multifunctional hydrogel can not only self-adaptively change the microenvironment to a pro-healing state by decreasing oxidative stress,but also respond to matrix metalloproteinases to release DFO.The self-adaptive multifunctional hydrogel has a potential for treating diabetic wounds.

关 键 词：Wound microenvironment Self-adaptive hydrogel MMP-9 responsive ANGIOGENESIS Diabetic wound healing 

分 类 号：R587.1[医药卫生—内分泌]