Red honeybush(Cyclopia genistoides)tea mitigates oxidative imbalance and hyperlipidemia,while improving glucose homeostasis in type 2 diabetic rats  

作　　者：Xin Xiao Ochuko L.Erukainure Md.Shahidul Islam 

机构地区：[1]Department of Biochemistry,University of KwaZulu-Natal,Westville Campus,Durban 4000,South Africa [2]Department of Pharmacology,University of the Free State,Bloemfontein 9300,South Africa

出　　处：《Food Science and Human Wellness》2023年第6期2029-2039,共11页食品科学与人类健康（英文）

基　　金：supported by a competitive research grant from the Research Office,University of KwaZulu-Natal(UKZN),Durban;an incentive grant for rated researchers and a grant support for women and young researchers from the National Research Foundation(NRF),Pretoria,South Africa.

摘　　要：Red honeybush tea(RHT)is a tea product developed from Cyclopia spp.which is endemic to South Africa.Aside refreshment,RHT has over the years been used traditionally in the treatment of various diseases including type 2 diabetes.This study investigated the in vivo antioxidant and anti-diabetic activity of RHT concentrated hot water extract in type 2 diabetes(T2D)model of rats.T2D was induced starting with feeding 10%fructose solution ad libitum for 2 weeks followed by a single intraperitoneal injection of streptozotocin(40 mg/kg body weight(BW)).Five weeks of treatment of RHT led to significant(P<0.05)elevation in serum insulin,pancreaticβ-cell function,HDL-C levels with concomitant decrease in AST,ALT,ALP,urea,CK-MB,fructosamine,total cholesterol,triglycerides,LDL-C,and insulin resistance in diabetic rats.RHT also signifi cantly(P<0.05)decreased MDA levels and enhanced level of GSH,activity of SOD,catalase,GR in most of organs(pancreas,liver,kidneys,and heart).Signifi cantly(P<0.05)improved morphological changes in the islets andβ-cells were observed in rats treated with RHT.The data of this study suggest that RHT demonstrates an outstanding antioxidant and anti-diabetic effects in STZ-induced T2D model of rats.

关 键 词：Red honeybush tea(Cyclopia genistoides) ANTIOXIDANTS Anti-diabetes Type 2 diabetes 

分 类 号：TS272[农业科学—茶叶生产加工]