Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review  

作　　者：Feixuan Wang Jingqiong Wan Yangzhen Liao Shangyu Liu Yuan Wei Zhen Ouyang 

机构地区：[1]School of Pharmacy,Jiangsu University,Zhenjiang 212013,China [2]Nanjing Institute of Product Quality Inspection,Nanjing 210019,China [3]School of Food and Biological Engineering,Jiangsu University,Zhenjiang 212013,China

出　　处：《Food Science and Human Wellness》2023年第6期2151-2174,共24页食品科学与人类健康（英文）

基　　金：funded by the National Key Research and Development Program of China(2018YFC1706105);the National Natural Science Foundation of China(81872961);Key Project at Central Government Level(2060302);Collaborative Innovation Project of Dendrobium Industrialization Development in Anhui Province.

摘　　要：Brain energy homeostasis is a vital physiological function in maintaining a balanced internal metabolic environment.The impairment of energy homeostasis is recognized as a key pathophysiological basis for brain metabolic disorders and related neurodegenerative diseases.Dendrobium species(‘Shihu’in Chinese)such as D.officinale,D.huoshanense,D.nobile,D.chrysanthum,D.loddigesii,D.moniliforme,D.gratiosissimum,D.candidum and D.caulis are widely used as traditional Chinese medicines/nutraceuticals to control and treat neurodegenerative disorders.These dietary herbs and their derived compounds possess a variety of biological properties,such as suppression of oxidative stress and neuroinflammation,regulation of energy homeostasis mainly through improving brain mitochondria function,insulin signaling and lipid metabolism.Furthermore,they reduce neurotoxicity,alleviate brain injury and neuropathy,and prevent neurodegenerative conditions including stroke,Alzheimer’s disease,Parkinson’s disease,and Huntington’s disease in humans and/or rodents.Moreover,the nutraceuticals from Dendrobium species promote gut health and aid digestion,which appear to be associated with beneficial effects on brain energy homeostasis.Based on the above-mentioned health benefits associated with Dendrobium species,this work reviews their nutraceutical role in neurodegenerative disorders and further suggests the need to elucidate mechanisms of the underlying molecular actions.

关 键 词：Dendrobium species Nutraceutical role Energy homeostasis Neurodegenerative diseases 

分 类 号：TS201.4[轻工技术与工程—食品科学]