Nigella sativa oil as a treatment for gingivitis: A randomized active-control trial  

作　　者：Ishrat Rahman Afrah Mohammed Manal A.AlSheddi Alanoud Algazlan Alanoud Alwably Mamata Hebbal Maha Galal Omar 

机构地区：[1]Department of Basic Dental Sciences,College of Dentistry,Princess Nourah bint Abdulrahman University,P.O.Box 84428,Riyadh 11671,Saudi Arabia [2]Department of Biology,College of Science,Princess Nourah bint Abdulrahman University,P.O.Box 84428,Riyadh 11671,Saudi Arabia [3]College of Dentistry,Princess Nourah bint Abdulrahman University,P.O.Box 84428,Riyadh 11671,Saudi Arabia [4]Department of Preventative Dental Sciences,College of Dentistry,Princess Nourah bint Abdulrahman University,P.O.Box 84428,Riyadh 11671,Saudi Arabia

出　　处：《Asian Pacific Journal of Tropical Medicine》2023年第3期129-138,共10页亚太热带医药杂志（英文版）

基　　金：Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2023R179);Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia。

摘　　要：Objective: To assess the clinical anti-inflammatory and antimicrobial efficacy of Nigella sativa oil compared with chlorhexidine in patients with gingivitis. Methods: A double-blind, randomized clinical trial was conducted in patients having chronic generalized gingivitis. Patients were randomly assigned to receive Nigella sativa oil(n=18) or chlorhexidine(n=19). The following assessments were made on day 0 and day 15: plaque index, gingival index, gingival IL-6 and IL-18 levels were measured using ELISA, plaque colony-forming units, and alpha-hemolytic Streptococcus strains. Data were analyzed using parametric and non-parametric tests and Fisher’s exact test.Results: Both interventions reduced plaque index and gingival index scores(P<0.000 1). The Nigella sativa oil group was better at lowering IL-6(P=0.007 6) than the chlorhexidine group(P=0.145), although there was no change in IL-18 levels(P>0.05). The post-intervention plaque index and gingival index scores and inflammatory cytokine levels between the two groups were not significantly different. Both interventions caused a significant reduction in the plaque colony-forming units(P<0.000 1), reducing pathogenic bacteria: Streptococcus mitis, Streptococcus oralis, Streptococcus sanguinis, and Streptococcus parasanguinis in the chlorhexidine group(50%)(P=0.103 1), and the Nigella sativa oil group(20%)(P=0.739 5). Conclusions: Nigella sativa oil had anti-inflammatory and antibacterial activities, reducing biofilm formation and disrupting the colonization of pathogenic bacteria essential for the progression of periodontal disease. Nigella sativa oil could offer an alternative therapy for treating gingivitis and may prevent associated systemic diseases and improve overall health outcomes.

关 键 词：CHLORHEXIDINE Mouth rinse INTERLEUKIN Gingival index Plaque index 

分 类 号：R781.41[医药卫生—口腔医学]