自拟中药灌肠方联合美沙拉秦缓释颗粒治疗溃疡性直肠炎的效果及对患者中医证候积分的影响  

Effect of self-made traditional Chinese medicine enema formula combined with mesalazine sustained-release granules in the treatment of ulcerative proctitis and its influence on patients'Chinese medicinal symptom score

作　　者：丁晓红[1] 范从畑 许建勇[1] 顾建忠 黄建辉 DING Xiao-hong;FAN Cong-tian;XU Jian-yong;GU Jian-zhong;HUANG Jian-hui(Nantong Traditional Chinese Medicine Hospital,Nantong 226001;Qidong Fifth People's Hospital,Nantong 226231,Jiangsu,China)

机构地区：[1]南通市中医院,江苏南通226001 [2]启东市第五人民医院,江苏南通226231

出　　处：《川北医学院学报》2023年第4期530-533,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨自拟中药灌肠方联合美沙拉秦缓释颗粒治疗溃疡性直肠炎的效果及对患者中医证候积分的影响。方法:选取108例溃疡性直肠炎患者为研究对象,按照治疗方案不同分为研究组和对照组,每组各54例。研究组患者采用自拟中药灌肠方联合美沙拉秦缓释颗粒治疗;对照组患者采用单纯美沙拉秦缓释颗粒治疗,疗程均为6周。比较两组患者临床疗效、血小板计数(PLT)、血小板平均体积(MPV)、血清C反应蛋白(CRP)水平、中医证候积分和不良反应发生率。结果:治疗后,研究组治疗总有效率高于对照组(P<0.05)。两组患者PLT、血清CRP水平均降低(P<0.05),且研究组低于对照组(P<0.05);MPV水平均升高,且研究组高于对照组(P<0.05);研究组患者中医证候积分低于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:自拟中药灌肠方联合美沙拉秦缓释颗粒治疗溃疡性直肠炎,能有效改善患者临床症状,疗效确切,安全性高。Objective:To investigate the effect of self-made Chinese herbal enema formula combined with mesalazine sustained-release granules in the treatment of ulcerative proctitis and its influence on the score of traditional Chinese medicine syndromes.Methods:108 patients with ulcerative proctitis were selected as subjects,and divided into the study group and the control group according to different treatment schemes,with 54 cases in each group.The study group was treated with self-made Chinese herbal enema formula combined with mesalazine sustained-release granules,and the control group was treated with mesalazine sustained-release granules alone for 6 weeks.The efficacy,platelet count(PLT),mean platelet volume(MPV),C-reactive protein(CRP),Chinese medicinal symptom score and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was higher than that of the control group(P<0.05).After treatment,the levels of PLT and CRP in the two groups were lower than those before treatment,and the study group was lower than the control group(P<0.05).The level of MPV in the two groups all increased,and the study group was higher than the control group(P<0.05).The Chinese medicinal symptom score of the study group was lower than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The treatment of ulcerative proctitis with self-made Chinese herbal enema formula combined with mesalazine sustained-release granules can effectively improve the clinical symptoms of patients,with definite curative effect and high safety.

关 键 词：溃疡性直肠炎 中药灌肠 美沙拉秦 中医证候积分 安全性 

分 类 号：R574.63[医药卫生—消化系统]