自噬在肝细胞癌中的作用机制研究进展  

Research Progress on the Mechanisms of Autophagy inHepatocellular Carcinoma

作　　者：陈怡璇 王琳[2] 夏秀宏[3] 彭在坤 丁奕 史润娇 雷学芬 CHEN Yixuan;WANG Lin;XIA Xiuhong;PENG Zaikun;DING Yi;SHI Runjiao;LEI Xuefen(Dept.of Oncology,The 2nd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101,China;Dept.of Hepatobiliary Surgery,The 2nd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101,China;Dept.of Traditional Chinese Medicine,The 2nd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101,China)

机构地区：[1]昆明医科大学第二附属医院肿瘤科,云南昆明650101 [2]昆明医科大学第二附属医院肝胆胰外科,云南昆明650101 [3]昆明医科大学第二附属医院中医科,云南昆明650101

出　　处：《昆明医科大学学报》2023年第4期159-164,共6页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81860423);云南省教育厅科学研究基金资助项目(2019J1263)。

摘　　要：肝细胞癌是世界上最常见的恶性肿瘤之一,具有恶性程度高、发展速度快等特点,大多数患者一经诊断已无法手术切除。因此,非手术治疗起着越来越重要的作用。尽管近年来随着药物的研发及放射治疗技术的革新,促进了肝细胞癌的疗效取得了较大的进步,但是由于其复发率高、常常出现治疗抵抗等情况使肝细胞癌患者的预后仍然不理想。肝细胞癌的发生、发展是多基因、多事件异常累积的结果,自噬调控过程的失调与肝癌的发生有关。自噬与肝细胞癌的发生发展、转移复发、治疗抵抗有着密切的关系。对自噬在肝细胞癌中的作用机制进行综述,为未来自噬的抗肿瘤研究提供参考。Hepatocellular carcinoma(HCC),characterized by high malignancy and rapid development,is one of the most common malignant tumors in the world.In most cases the tumor is inoperable when diagnois is made.Therefore,non-surgical treatment plays an increasingly important role.Although the curative effect of hepatocellular carcinoma has made great progress in recent years with the development of drugs and the innovation of radiotherapy technology,the prognosis of patients with hepatocellular carcinoma is still not ideal due to its high recurrence rate and frequent resistance to treatment.The development of hepatocellular carcinoma is the result of abnormal accumulation of multiple genes and cellular events.The autophagy dysregulation can cause the occurrence of hepatocellular carcinoma.Autophagy is closely related to the occurrence and development,metastasis and recurrence,and resistance to treatment of hepatocellular carcinoma.This paper aims to review the mechanisms of autophagy in hepatocellular carcinoma and provide reference for future anti-tumor studies on autophagy.

关 键 词：自噬 肝细胞癌 研究进展 

分 类 号：R735.7[医药卫生—肿瘤]