Pt(Ⅳ) prodrug initiated microparticles from microfluidics for tumor chemo-, photothermal and photodynamic combination therapy  

作　　者：Qingfei Zhang Xiaocheng Wang Gaizhen Kuang Yuanjin Zhao 

机构地区：[1]Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing,210096,China [2]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,325001,China

出　　处：《Bioactive Materials》2023年第6期185-196,共12页生物活性材料（英文）

基　　金：supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52103196 and 52073060);Guangdong Basic and Applied Basic Research Foundation(2021B1515120054);the Shenzhen Fundamental Research Program(JCYJ20190813152616459 and JCYJ20210324133214038).

摘　　要：Multimodal treatment modalities hold great potential for cancer therapy,thus current efforts are focusing on the development of more effective and practical synergistic therapeutic platforms.Herein,we present a novel trans,trans,trans-[Pt(N_(3))_(2)(OH)_(2)(py)_(2)](Pt(Ⅳ))prodrug-initiated hydrogel microparticles(M_(ICG-Pt))with indocyanine green(ICG)encapsulation by microfluidics for efficiently synergistic chemo-,photothermal(PTT)and photodynamic therapy(PDT).The employed Pt(Ⅳ)could not only serves as an initiator to generate azidyl radical(N_(3)^(·))for photo-polymerization of methacrylate gelatin(GelMA)matrix,but also be reduced to high cytotoxic platinum(Ⅱ)(Pt(Ⅱ))species for tumor chemotherapy.The laden ICG with highly photothermal heating ability and intrinsic reactive oxygen species(ROS)productivity endows the M_(ICG-Pt) with effective PTT/PDT performances upon near-infrared(NIR)light irradiation.In addition,benefiting from the production of oxygen during the photo-activation process of Pt(Ⅳ),the PDT efficacy of ICG-laden M_(ICG-Pt) could be further enhanced.Based on these advantages,we have demonstrated that the M_(ICG-Pt) could significantly eliminate cancer cells in vitro,and remarkably suppressed the tumor growth in vivo via synergistic chemotherapy,PTT,and PDT.These results indicate that such Pt(Ⅳ)-initiated hydrogel microparticles are ideal candidates of multimodal treatment platforms,holding great prospects for cancer therapy.

关 键 词：MICROFLUIDICS Hydrogel microparticle Chemotherapy PHOTOTHERMAL Photodynamic Cancer therapy 

分 类 号：R730.5[医药卫生—肿瘤]