Lubricant skin on diverse biomaterials with complex shapes via polydopamine-mediated surface functionalization for biomedical applications  

作　　者：Kijun Park Seunghoi Kim Yejin Jo Jae Park Inwoo Kim Sooyoung Hwang Yeontaek Lee So Yeon Kim Jungmok Seo 

机构地区：[1]School of Electronic and Electronic Engineering,Yonsei University,Seoul,03722,Republic of Korea [2]Center for Biomaterials,Biomedical Research Institute,Korea Institute of Science and Technologies,Seoul,02792,Republic of Korea [3]Center for Theragnosis,Biomedical Research Institute,Korea Institute of Science and Technologies,Seoul,02792,Republic of Korea

出　　处：《Bioactive Materials》2023年第7期555-568,共14页生物活性材料（英文）

基　　金：This research was supported by Nano⋅Material Technology Development Program through the National Research Foundation of Korea(NRF)funded by Ministry of Science and ICT(NRF-2021M3H4A1A03048658,NRF-2021M3H4A1A04092883).

摘　　要：Implantable biomedical devices require an anti-biofouling,mechanically robust,low friction surface for a prolonged lifespan and improved performance.However,there exist no methods that could provide uniform and effective coatings for medical devices with complex shapes and materials to prevent immune-related side effects and thrombosis when they encounter biological tissues.Here,we report a lubricant skin(L-skin),a coating method based on the application of thin layers of bio-adhesive and lubricant-swellable perfluoropolymer that impart anti-biofouling,frictionless,robust,and heat-mediated self-healing properties.We demonstrate biocompatible,mechanically robust,and sterilization-safe L-skin in applications of bioprinting,microfluidics,catheter,and long and narrow medical tubing.We envision that diverse applications of L-skin improve device longevity,as well as anti-biofouling attributes in biomedical devices with complex shapes and material compositions.

关 键 词：Anti-biofouling Lubricant-infused Biomedical applications BIOMATERIALS BIOINTERFACE 

分 类 号：R318.08[医药卫生—生物医学工程]