Rapid sterilisation and diabetic cutaneous regeneration using cascade bio-heterojunctions through glucose oxidase-primed therapy  

作　　者：Yi Deng Xumei Ouyang Jiyu Sun Xiuyuan Shi Yunfei Li Yau Kei Chan Weizhong Yang Shaojun Peng 

机构地区：[1]College of Biomedical Engineering,School of Chemical Engineering,Sichuan University,Chengdu,610065,China [2]State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu,610065,China [3]Zhuhai Institute of Translational Medicine,Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University),Zhuhai,Guangdong,519000,China [4]State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu,610041,China [5]Department of Materials,Imperial College London,SW72AZ,London,United Kingdom [6]Department of Biomedical Engineering,The City College of the City University of New York,New York,United States [7]Department of Mechanical Engineering,The University of Hong Kong,Hong Kong,China [8]Department of Ophthalmology,The University of Hong Kong,Hong Kong,China

出　　处：《Bioactive Materials》2023年第7期748-765,共18页生物活性材料（英文）

基　　金：This work is jointly funded by the National Natural Science Foundation of China(81961160736,81801848,82172073,8217070298);Natural Science Foundation of Sichuan Province(2022NSFSC0361);Sichuan Science and Technology Program(2021YJ0049);Chengdu International Science and Technology Cooperation Foundation(2020-GH03-00005-HZ,2017-GH02-00025-HZ);State Key Laboratory of Polymer Materials Engineering(sklpme2019-2-05);Young Elite Scientist Sponsorship Program by CAST,Sichuan University-Luzhou City Special Funding for Strategic Cooperation(2020CDLZ-5).

摘　　要：The cutaneous wound in diabetic patients frequently encounters intractable pathogenic infections due to the hyperglycemia micromilieu which is conducive to bacterial growth and multiplication.Despite the extensive clinical use of antibiotics to treat bacterial infections,the emergence of drug-resistant and super pathogens as well as the potential side effects of antibiotics have elicited alarming challenges to public health.To address this daunting concern,we devise and develop a photo-activated cascade bio-heterojunctions(C-bio-HJs)for rapid sterilization and diabetic cutaneous regeneration.In the designed C-bio-HJs,photo-generated electron-hole pairs of graphite-phase carbon nitride(g-C_(3)N_(4))are effectively separated with the marriage of molybdenum disulfide(MoS_(2)),which achieves the augmented photodynamic antibacterial effect.Moreover,glucose oxidase(GOx)tethered on the bio-HJs catalyzes glucose into hydrogen peroxide(H_(2)O_(2))in diabetic wounds for starvation therapy.Furthermore,Mo4+enables the catalysis of H_(2)O_(2)into a highly effective hydroxyl radical(⋅OH)for chemodynamic-photothermal combined antibacterial therapy.Both in vitro and in vivo results authenticate the cascading antibacterial properties and skin regeneration-promoting effects of the C-bio-HJs,which provide a facile strategy to combat diabetic wound healing through the synergistic GOx-primed dynamic therapies.

关 键 词：Antibacterial therapy Bio-heterojunction g-C_(3)N_(4) Rapid sterilization Tissue regeneration 

分 类 号：R738.1[医药卫生—肿瘤]