注射用丹参多酚酸联合阿替普酶静脉溶栓治疗急性脑梗死的效果及对神经保护因子、血管再通的影响  

Effect of salvianolic acid for injection combined with alteplase intravenous thrombolysis in the treatment of acute cerebral infarction and its influences on neuroprotective factors and vascular recanalization

作　　者：任君花 李冬梅 鲁琳 REN Junhua;LI Dongmei;LU Lin(Sanyuan County Hospital,Xianyang 713800;No.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000,China)

机构地区：[1]三原县医院,陕西咸阳713800 [2]陕西省核工业二一五医院,陕西咸阳712000

出　　处：《临床医学研究与实践》2023年第12期20-23,共4页Clinical Research and Practice

摘　　要：目的探讨注射用丹参多酚酸联合阿替普酶静脉溶栓治疗急性脑梗死的临床效果。方法选取2019年3月至2021年3月收治的100例急性脑梗死患者为研究对象,根据治疗方法不同将其分为对照组与观察组,各50例。对照组采用阿替普酶静脉溶栓治疗,观察组在对照组基础上加注射用丹参多酚酸治疗。比较两组的治疗效果。结果治疗后,观察组的双侧大脑前动脉(ACA)、大脑中动脉(MCA)、大脑后动脉(PCA)及左右椎动脉(VA)平均血流速度高于对照组(P<0.05)。治疗后,观察组的胶质纤维酸性蛋白(GFAP)水平低于对照组,神经生长因子(NGF)、血浆脑源性神经营养因子(BDNF)水平高于对照组(P<0.05)。治疗后,观察组的血浆黏度(PV)、红细胞最大凝集指数(MAXD)及D-二聚体(D-D)、纤维蛋白原(FIB)水平均低于对照组(P<0.05)。观察组治疗后的血管再通情况优于对照组(P<0.05)。结论注射用丹参多酚酸联合阿替普酶静脉溶栓治疗急性脑梗死可有效改善脑血流动力学及血液流变学,调节神经保护因子水平,提高血管再通率。Objective To explore the clinical effect of salvianolic acid for injection combined with alteplase intravenous thrombolysis in the treatment of acute cerebral infarction.Methods A total of 100 patients with acute cerebral infarction admitted from March 2019 to March 2021 were selected as the research objects and divided into control group and observation group according to different treatment methods,with 50 cases in each group.The control group was treated with alteplase intravenous thrombolysis,and the observation group was treated with salvianolic acid for injection on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the average blood flow velocity of bilateral anterior cerebral artery(ACA),middle cerebral artery(MCA),posterior cerebral artery(PCA)and left and right vertebral artery(VA)in the observation group were higher than those in the control group(P<0.05).After treatment,the level of glial fibrillary acidic protein(GFAP)in the observation group was lower than that in the control group,while the levels of nerve growth factor(NGF)and plasma brain-derived neurotrophic factor(BDNF)in the observation group were higher than those in the control group(P<0.05).After treatment,the plasma viscosity(PV),red blood cell maximum agglutination index(MAXD),d-dimer(D-D)and fibrinogen(FIB)levels in the observation group were lower than those in the control group(P<0.05).The vascular recanalization in the observation group after treatment was better than that in the control group(P<0.05).Conclusion Salvianolic acid for injection combined with alteplase intravenous thrombolysis in the treatment of acute cerebral infarction can effectively improve cerebral hemodynamics and hemorheology,regulate the level of neuroprotective factors,and improve the rate of vascular recanalization.

关 键 词：注射用丹参多酚酸 阿替普酶静脉溶栓 急性脑梗死 神经保护因子 血管再通 

分 类 号：R743.3[医药卫生—神经病学与精神病学]