原发性肝细胞性肝癌患者术后癌旁组织CXCR4表达的影响因素与术后生存时间  

Study on the influencing factors of CXCR4 expression in paracancerous tissue and postoperative survival time in patients with primary hepatocellular carcinoma after surgery

作　　者：吴梅梅[1] 王靖雯 魏丽丽 黄富妹 黄警 郑益武 朱琪[1] WU Meimei;WANG Jingwen;WEI Lili;HUANG Fumei;HUANG Jing;ZHENG Yirwu;ZHU Qi(Department of Infection Control,Fuzhou Municipal Second Hospital,Fuzhou,Fujian 350007,China)

机构地区：[1]福建省福州市第二医院感控科,福州350007

出　　处：《福建医药杂志》2023年第2期8-11,共4页Fujian Medical Journal

摘　　要：目的探究原发性肝细胞性肝癌患者术后癌旁组织中CXCR4表达情况的影响因素与术后生存时间。方法收集34例原发性肝细胞性肝癌手术病例的一般情况及临床特征并进行定期随访。使用免疫组织化学法检测原发性肝细胞性肝癌患者的癌组织及癌旁组织中CXCR4的表达情况。比较癌旁组织CXCR4不同表达时的一般情况及临床指征;利用Kaplan-Meier法绘制生存曲线,Log-rank检验进行不同癌旁组织CXCR4表达的术后生存率的比较。结果随访截至2022年6月,19例癌旁组织CXCR4阳性表达患者中死亡8例,17例癌旁组织CXCR4阴性表达患者中死亡1例。有HBsAg携带、Child分级B级以及有饮酒史的肝癌患者,术后癌旁组织中CXCR4的阳性表达率较高,差异均有统计学意义(P<0.05)。癌旁组织CXCR4阳性患者术后生存率低于阴性患者(Log-rankχ^(2)=5.89,P=0.015)。结论术后癌旁组织CXCR4的表达情况对原发性肝细胞性肝癌术后患者的预后有影响。Objective To investigate the influencing factors of CXCR4 expression in paracancerous tissue and postopera-tive survival time in patients with primary hepatocellular carcinoma after surgery.Methods The general information and clinical characteristics of 34 cases of primary hepatocellular carcinoma were collected and followed up regularly.The expression of CX-CR4 in cancer and paracancerous tissues of patients with primary hepatocellular carcinoma was detected by immunohistochemical method.The patients were divided into two groups according to different expression of CXCR4 in paracancerous tissues.Survival rates were calculated by using the Kaplan Meier method and compared by using the Log rank test.Results The follow-up ended in June 2022.Eight of the 19 patients with positive CXCR4 expression in paracancerous tissues died,and one of the 17 patients with CXCR4 negative expression in paracancerous tissues died.Patients with HBsAg carriage,Child grade B,and a history of alcohol consumption had higher positive expression of CXCR4 in postoperative paracancerous tissues,and all these differ-ences were statistically significant(P<0.05).The survival rate of patients with positive CXCR4 expression in paracancerous tissues was lower than that of patients with negative CXCR4 expression(Log-rank χ^(2)=5.89,P=0.015).Conclusion The ex-pression of CXCR4 in paracancerous tissue has an impact on the prognosis of patients with primary hepatocellular carcinoma after surgery.

关 键 词：原发性肝癌 癌旁组织 CXCR4 生存期 

分 类 号：R735.7[医药卫生—肿瘤]