中国四省55岁及以上人群帕金森病前驱期现状及人口经济学特征  

Prodromal Parkinson’s disease and its socio-demographic characteristics among people aged 55 and above in four provinces of China

作　　者：张思婷 王柳森 姜红如 贾小芳 张继国 李惟怡 黄绯绯 王惠君 张兵 王志宏 ZHANG Siting;WANG Liusen;JIANG Hongru;JIA Xiaofang;ZHANG Jiguo;LI Weiyi;HUANG Feifei;WANG Huijun;ZHANG Bing;WANG Zhihong(National Institute for Nutrition and Health,Chinese Center for Disease Control and Prevention,Beijing 100050,China)

机构地区：[1]中国疾病预防控制中心营养与健康所,北京100050

出　　处：《环境与职业医学》2023年第2期122-128,共7页Journal of Environmental and Occupational Medicine

基　　金：国家重点研发计划项目(2017YFC0907701);国家财政项目(131031107000210002)。

摘　　要：[背景]近年来,中国老龄化进程加快,帕金森病的患病形势日益严峻,其疾病前期阶段及相关影响因素的研究日益受到关注。[目的]了解中国四省55岁及以上人群的帕金森病前驱期(pPD)现状,并探讨人口学特征和社会经济状况对pPD的影响。[方法]利用“神经系统疾病专病社区队列研究”2020年调查数据,选取具有完整人口学和社会经济学信息、帕金森病风险因素筛查数据的10 724名55岁及以上研究对象。依据国际帕金森病和运动障碍协会研究标准评估研究对象的pPD风险水平(即后验概率)、可能或极可能的pPD检出率及相关风险/前驱标志数。分别采用多重线性回归模型和多因素logistic回归模型分析人口经济因素与pPD风险水平和可能或极可能的pPD的关系;采用Poisson回归模型和多项logit回归模型分析人口经济因素与pPD风险/前驱标志数的关联并对性别进行分层分析。[结果]2020年中国四省55岁及以上人群pPD后验概率的中位数(P25,P75)水平为0.78%(0.42%,1.66%),可能或极可能的pPD检出率为0.34%,有69.03%的研究对象具有3~5个pPD风险/前驱标志。男性、年龄越高、文化程度越低、家庭人均月收入<1 000元、居住在城市、无工作者的pPD后验概率较高(P <0.05);男性和≥75岁者可能或极可能的pPD检出率高于其他组(P <0.05)。≥75岁人群检出可能或极可能的pPD的可能性高于55~64岁组(OR=8.404,95%CI:2.839~24.879)。男性、无工作者、低文化程度者、高龄老人及城市居民出现pPD风险/前驱标志的可能性高于相应的特征人群(P <0.05)。[结论]我国四省55岁及以上人群中男性、≥75岁、文化程度低、居住在城市以及无工作者的pPD风险水平更高并更有可能出现风险/前驱标志,经济状况较差也与较高的pPD风险水平相关。[Background] China is witnessing an accelerated aging process and an increasingly serious situation of Parkinson’s disease. Research on the pre-disease stage and its related influencing factors has gained more and more attention.[Objective] To analyze the current situation of prodromal Parkinson’s disease(pPD) of people aged 55 years and above in four provinces of China, and to explore its influencing demographic and socio-economic characteristics.[Methods] Using the data of Community-based Cohort Study on Nervous System Disease in 2020,a total of 10 724 participants with complete data on demographic and socio-economic factors and risk factors on Parkinson’s disease were selected. Based on the criteria recommended by the International Parkinson and Movement Disorder Society(MDS), we evaluated risk level(i.e., post-test probability) of pPd, prevalence of possible or probable pPD, and number of pPD-related risk/prodromal markers in the participants.Multiple linear regression and multiple logistic regression models were used to analyze the influencing socio-demographic factors of risk level of pPd and prevalence of possible or probable pPD, and Poisson regression and multinomial logit regression models were used to analyze the influencing socio-demographic factors of the number of pPD-related risk/prodromal markers in the total sample, men, and women, respectively.[Results] The median(P25, P75) of post-test probability of pPD in 2020 was 0.78%(0.42%, 1.66%), the prevalence rate of possible or probable pPD was 0.34%, and 69.03% of the participants reported 3-5 pPD-related risk/prodromal markers. The post-test probabilities of men,those with older age, lower education level, per capita monthly household income < 1 000 yuan, urban residency, or without active employment were higher(P < 0.05). Men and being aged ≥ 75 years had a higher prevalence of possible or probable pPD(P < 0.05). The OR of possible or probable pPD was 8.404(95%CI: 2.839-24.879) in subjects aged ≥ 75 years versus those aged 55-64 years. Ma

关 键 词：帕金森病前驱期 55岁及以上人群 人口学 社会经济学 风险标志 前驱标志 

分 类 号：R15[医药卫生—营养与食品卫生学]