D-二聚体、BNP及PCT预测长期卧床患者下肢深静脉血栓的价值研究  

Predictive Value of D-dimer,BNP and PCT in Lower Extremity Deep Venous Thrombosis in Long-term

作　　者：任一梦 李军民[1] 郭子昆 REN Yi-meng;LI Jun-min;GUO Zi-kun(Jiaozuo People's Hospital,Henan Jiaozuo 454002)

机构地区：[1]焦作市人民医院,河南焦作454002

出　　处：《深圳中西医结合杂志》2023年第4期28-30,F0003,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:研究外周血D-二聚体、B型尿钠肽(BNP)及降钙素原(PCT)联合检测在长期卧床患者下肢深静脉血栓中的预测价值。方法:选取焦作市人民医院2022年1月至2022年6月诊治的80例长期卧床患者为研究对象,根据患者有无下肢深静脉血栓分为下肢深静脉血栓组(观察组)与无下肢深静脉血栓组(对照组)。检测并比较两组患者D-二聚体、BNP及PCT差异。采用logistic回归分析长期卧床患者下肢深静脉血栓影响因素。采用受试者工作特征曲线(ROC)分析外周血D-二聚体、BNP及PCT联合检测预测长期卧床患者下肢深静脉血栓灵敏度及特异度。结果:观察组患者D-二聚体、BNP及PCT水平均显著高于对照组,差异均具有统计学意义(P<0.05);多因素logistic回归分析结果表明,D-二聚体、BNP及PCT均为长期卧床患者下肢深静脉血栓危险因素(P<0.05);D-二聚体、BNP、PCT预测长期卧床合并下肢深静脉血栓的灵敏度分别为0.975、0.900、0.950,特异度分别为1.000、0.975、1.000。D-二聚体、BNP、PCT预测长期卧床合并下肢深静脉血栓截断值分别为5.46 mg·L^(-1)、111.87 pg·mL^(-1)、3.25 mg·L^(-1)。结论:D-二聚体、BNP及PCT联合检测可为长期卧床患者下肢深静脉血栓预测提供参考。Objective To study the predictive value of combined detection of peripheral blood D-dimer,B-type natriuretic peptide(BNP)and procalcitonin(PCT)in lower extremity deep vein thrombosis in long-term bedridden patients.Methods A total of 80 long-term bedridden patients diagnosed and treated in Jiaozuo People's Hospital from January 2022 to June 2022 were selected as the research objects.According to whether the patients had lower extremity deep venous thrombosis,they were divided into lower extremity deep venous thrombosis group(an observation group)and no lower extremity deep venous thrombosis group(a control group).The differences in D-dimer,BNP and PCT were detected and compared between the two groups.Logistic regression analysis of influencing factors of lower extremity deep venous thrombosis in long-term bedridden patients.To analyze the sensitivity and specificity of combined detection of peripheral blood D-dimer,BNP and PCT in predicting lower extremity deep venous thrombosis in long-term bedridden patients.Results The levels of D-dimer,BNP,and PCT in the observation group were significantly higher than those in the control group,and the differences were statistically significant(all P<0.05).Logistic regression analysis showed that D-dimer,BNP and PCT were influencing factors of lower extremity deep venous thrombosis in long-term bedridden patients(P<0.05).The sensitivities of D-dimer,BNP,and PCT in predicting long-term bed rest combined with lower extremity deep venous thrombosis were 0.975,0.900,and 0.950,and the specificities were 1.000,0.975,and 1.000,respectively.The cut-off values of D-dimer,BNP,and PCT in predicting long-term bed rest combined with lower extremity deep venous thrombosis were 5.46 mg·L^(-1),111.87 pg·mL^(-1),and 3.25 mg·L^(-1),respectively.Conclusion The combined detection of D-dimer,BNP and PCT can provide reference for the prediction of deep venous thrombosis of lower limbs in long-term bedridden patients.

关 键 词：下肢深静脉血栓 长期卧床 D-二聚体 B型尿钠肽 降钙素原 

分 类 号：R364.15[医药卫生—病理学]