Drug-loaded balloon with built-in NIR controlled tip-separable microneedles for long-effective arteriosclerosis treatment  

作　　者：Li Huang Huaqiang Fang Teng Zhang Binbin Hu Shichen Liu Fanzhen Lv Zhaoxia Zeng Huijie Liu Weimin Zhou Xiaolei Wang 

机构地区：[1]Department of Vascular Surgery,The Second Affiliated Hospital of Nanchang University,Nanchang University,Nanchang,Jiangxi,330006,PR China [2]The National Engineering Research Center for Bioengineering Drugs and the Technologies,Institute of Translational Medicine,Nanchang University,Nanchang,Jiangxi,330088,PR China [3]Department of Radiology,The Second Affiliated Hospital of Nanchang University,Nanchang University,Nanchang,Jiangxi,330006,PR China [4]School of Chemistry and Chemical Engineering,Nanchang University,Nanchang,Jiangxi,330088,PR China

出　　处：《Bioactive Materials》2023年第5期526-538,共13页生物活性材料（英文）

基　　金：This work was funded by the National Natural Science Foundation of China(No.31860263 to Xiaolei Wang,No.82060095 to Weimin Zhou),Key Youth Project of Jiangxi Province(20202ACB216002 to Xiaolei Wang),Key Research and Development Project of Jiangxi Province(20212BBG73004 to Xiaolei Wang,20171ACG70008 to Weimin Zhou);Natural Science Foundation of Jiangxi Province(911135755018 to Weimin Zhou).

摘　　要：Drug-eluting balloon(DEB)angioplasty has emerged as an effective treatment for cardiovascular and cerebrovascular diseases.However,distal embolism and late lumen restenosis could be caused by drug loss during DEB handling and rapid drug metabolization.Here,a drug-loaded balloon equipped with tip-separable microneedles on the balloon surface(MNDLB)was developed.Inbuilt near-infrared(NIR)ring laser inside the catheter inner shaft was introduced to activate the biodegradable microneedle tips for the first time.The drug-loaded tips thus could be embedded in the vasculature and then released antiproliferative drug-paclitaxel slowly via polymer degradation for more than half a year.A significant increase in drug delivery efficiency and superior therapeutic effectiveness compared with the standard DEB were demonstrated using an atherosclerosis rabbit model.

关 键 词：Photothermal responsive Drug delivery MICRONEEDLES Atherosclerosis Drug-eluting balloon 

分 类 号：R543.4[医药卫生—心血管疾病]