住院精神疾病患者骨代谢相关指标调查  

Analyses of bone metabolism-related parameters in inpatient with psychiatric disorder

作　　者：张蕾[1] 朱明文 刘向群[1] 赵志君 吕路线[1] 韩勇[1] Zhang Lei;Zhu Mingwen;Liu Xiangqun;Zhao Zhijun;Lv Luxian;Han Yong(The Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan,China)

机构地区：[1]新乡医学院第二附属医院,河南新乡453002

出　　处：《临床心身疾病杂志》2023年第2期41-44,共4页Journal of Clinical Psychosomatic Diseases

基　　金：河南省医学科技攻关联合共建项目(编号LHGJ20220637)。

摘　　要：目的了解住院精神疾病患者骨代谢相关指标,为临床治疗提供依据。方法对933例成年住院精神疾病患者的临床资料进行回顾性分析,收集其骨钙素、甲状旁腺素、25-羟基维生素D_(3)、血钙和磷水平,并进行统计分析。结果933例精神疾病患者男683例(73.20%),女250例(26.80%),年龄(35.29±13.80)岁。女性患者骨钙素、25-羟基维生素D_(3)及血清总钙水平均显著低于男性患者(P<0.01)。不同精神疾病类型两两比较,双相情感障碍患者25-羟基维生素D_(3)水平显著高于精神分裂症患者(P<0.01),抑郁障碍患者无机磷水平显著高于精神分裂症患者、双相情感障碍患者(P<0.01)。偏相关分析显示,年龄与25-羟基维生素D_(3)水平呈显著正相关(r=0.185,P<0.01),与骨钙素、血清总钙、无机磷水平呈显著负相关(r=-0.274、-0.072、-0.089,P<0.05或0.01),病程与骨钙素、血清总钙水平呈显著负相关(r=-0.149、-0.083,P<0.05或0.01)。结论不同性别、精神疾病类型患者骨代谢存在一定程度的差异,且与年龄、疾病病程有关,精神卫生保健工作者应据此给予针对性的饮食干预。Objective To investigate the bone metabolism-related parameters in inpatients with psychiatric disorders in order to provide the basis for clinical treatment.Methods Clinical data of 933 inpatients with psychiatric disorders were retrospectively analyzed,such parameters collected as osteocalcin,parathyroid hormone,25-hydroxyvitamin D_(3),blood calcium and phosphorus levels,and statistical analyses conducted.Results Of 933 patients with psychiatric disorder 683(73.20%)were male and 250(26.80%)female,mean age was(35.29±13.80)years.The osteocalcin,25-hydroxyvitamin D_(3)and serum total calcium levels were significantly lower in female than in male patients(P<0.01).Paired comparison of different types of psychiatric disorders showed that 25-hydroxyvitamin D_(3)levels were significantly higher in patients with bipolar affective disorder than in ones with schizophrenia(P<0.01),so were inorganic phosphorus in depressive disorders than in schizophrenia and bipolar disorder(P<0.01).Partial correlation analyses showed that ages were positively correlated with 25-hydroxyvitamin D_(3)levels(r=0.185,P<0.01)and negatively with osteocalcin,total serum calcium and inorganic phosphorus(r=-0.274,-0.072,-0.089,P<0.05 or 0.01),and disease durations negatively with osteocalcin and serum total calcium(r=-0.149,-0.083,P<0.05 or 0.01).Conclusion There is a certain degree of difference in bone metabolism in patients with different genders and different types of mental diseases,which is correlated with ages and disease courses,and therefore mental health care workers should provide targeted diet intervention.

关 键 词：精神疾病 骨钙素 25-羟基维生素D 3 甲状旁腺素 

分 类 号：R749[医药卫生—神经病学与精神病学] R151.42[医药卫生—临床医学]