5-羟色胺转运体基因多态性与不同民族创伤后应激障碍患者的关联性研究  

Association between 5-HT transporter gene polymorphism and post-traumatic stress disorder in different nationalities

作　　者：李飞燕 郭敏[1] 蒋湘玲[1] 康延海[1] 郭骏成[1] 景嘉灏 LI Fei-yan;GUO Min;JIANG Xiang-ling;KANG Yan-hai;GUO Jun-cheng;JING Jia-hao(Department of Psychiatry,Hainan General Hospital,Haikou 570311,Hainan,CHINA)

机构地区：[1]海南省人民医院精神心理科,海南海口570311

出　　处：《海南医学》2023年第8期1076-1082,共7页Hainan Medical Journal

基　　金：国家自然科学基金(编号:81760255)。

摘　　要：目的探讨5-羟色胺转运体(5-HTTLPR)基因多态性与海南省黎、汉民族创伤后应激障碍(PTSD)患者的相关性。方法选取2017年10月至2018年7月在海南省人民医院就诊的308例PTSD患者作为研究组,其中黎族167例,汉族141例;另选2017年10月至2018年7月间未经受创伤性事件并在我院健康体检中心体检的158例健康志愿者作为对照组。收集研究对象的一般资料,采用PTSD临床评定量表、埃森创伤问卷(ETI)评定入组患者PTSD严重程度,另采用汉诺塔(TOH)、威斯康星卡片分类测试(WCST)、连线测验(TMT)与韦氏成人智力量表(WAIS)对评定入组对象认知功能,应用多聚酶链式反应(PCR)方法检测研究对象5-HTTLPR基因多态性。结果三组被试者的平均年龄、性别构成、婚姻状况和受教育程度比较差异均无统计学意义(P>0.05);黎族PTSD患者和汉族PTSD患者的各ETI评分与PTSD总分、TMT时间、TOH计划时间和执行时间、WCST的错误数明显高于对照组,而WAIS-RC中领悟、相似、木块图、物体拼凑及操作智商和TOH总分明显低于对照组,差异均有统计学意义(P<0.05);黎族PTSD患者各ETI评分与PTSD总分、TMT时间明显高于汉族PTSD患者,而WAIS-RC中领悟、操作智商与低于汉族PTSD患者,差异均具有统计学意义(P<0.05);黎族PTSD患者5-HTTLPR等位基因与基因型分布与对照组比较差异均无统计学意义(P>0.05),而在汉族PTSD患者与对照组中比较差异均有统计学意义(P<0.05):与LL基因型比较,SS基因型可能会增加汉族人群患PTSD的风险(OR=2.157,95%CI=1.098~4.237,P=0.024);与L等位基因比较,S等位基因可能会增加汉族人群患PTSD的风险(OR=1.456,95%CI=1.045~2.207,P=0.026);汉族PTSD患者中5-HTTLPR的SS基因型患者各ETI评分与PTSD总分、TMT时间明显高于LL基因型患者,WAIS-RC中的领悟和算术及木块图明显低于LL基因型患者,差异均具有统计学意义(P<0.05),而在黎族PTSD患者中SS基因型与LL基因型的认Objective To explore the relationship between 5-hydroxytryptamine transporter(5-HTTLPR)gene polymorphism and posttraumatic stress disorder(PTSD)in Li and Han nationalities in Hainan province.Methods A total of 308 patients with PTSD who were treated in Hainan General Hospital from October 2017 to July 2018 were selected as the study group,including 167 cases of Li nationality and 141 cases of Han nationality.Another 158 healthy volunteers who had not suffered a traumatic event and had a physical examination at Medical Examination Center from October 2017 to July 2018 were selected as the control group.The general data of the subjects was collected.The PTSD Clinical Rating Scale and the Eisen Trauma Questionnaire(ETI)was used to assess the severity of PTSD in the enrolled patients.The cognitive function of the enrolled subjects was assessed by the Hanoi Tower(TOH),Wisconsin Card Sorting Test(WCST),Trail Making Test(TMT),and Wechsler Adult Intelligence Scale(WAIS).The polymorphism of 5-HTTLPR gene was detected by polymerase chain reaction(PCR).The correlation with PTSD was statistically analyzed.Results There was no significant difference in average age,gender composition,marital status,and education level among the three groups(P>0.05).The ETI scores,PTSD total score,TMT time,TOH planning time and execution time,WCST error number of PTSD patients of Li nationality and Han nationality was significantly higher than those of the control group,while the scores of comprehension,similarity,block diagram,object patchwork and operation IQ and TOH total score in WAIS-RC were significantly lower than those of the control group(P<0.05).The ETI score,PTSD total score,and TMT time of PTSD patients of Li nationality was significantly higher than those of PTSD patients of Han nationality,while the scores of WAIS-RC was significantly lower than those of PTSD patients of Han nationality(P<0.05).There was no significant difference in the distribution of 5-HTTLPR genotypes and alleles between Li PTSD patients and the control group(P

关 键 词：创伤后应激障碍 黎族 汉族 5-羟色胺转运体基因多态性 认知功能 

分 类 号：R749[医药卫生—神经病学与精神病学]