Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis  

作　　者：Yixi Yang Le Wang Yonglin Zhou Yijun He Shaozhang Lin Yuwei Zeng Yunhe Zhou Wei Li Zaopeng He Qi Zhao Lihao Chen Zijie Li Wenhao Wang Zhi-Yong Zhang 

机构地区：[1]Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University,Guangdong Province Engineering Research Center for Biomedical Engineering,State Key Laboratory of Respiratory Disease,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,P.R.China [2]Department of Orthopaedic Surgery,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,P.R.China [3]Medical Technology and Related Equipment Laboratory,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,P.R.China [4]Hand and Foot Surgery&Plastic Surgery,Affiliated Shunde Hospital of Guangzhou Medical University,Shunde District,Foshan,P.R.China

出　　处：《Regenerative Biomaterials》2022年第1期202-218,共17页再生生物材料（英文版）

基　　金：supported by the National Natural Science Foundation of China(NSFC)(Nos.81772354,81902189,82072409);Clinical Innovation Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR0201002);Science Technology Project of Guangzhou City(201804010185);Natural Science Foundation of Guangdong Province(2019A1515012020);Science and Technology Innovation Project of Foshan City(1920001000025);National Young Thousand-Talent Scheme to Zhang Zhi-Yong.

摘　　要：Successful wound healing depends on the reconstruction of proper tissue homeostasis,particularly in the posttraumatic inflammatory tissue microenvironment.Diabetes jeopardizes tissues’immune homeostasis in cutaneous wounds,causing persistent chronic inflammation and cytokine dysfunction.Previously,we developed an autologous regeneration factor(ARF)technology to extract the cytokine composite from autologous tissue to restore immune homeostasis and promote wound healing.However,treatment efficacy was significantly compromised in diabetic conditions.Therefore,we proposed that a combination of melatonin and ARF,which is beneficial for proper immune homeostasis reconstruction,could be an effective treatment for diabetic wounds.Our research showed that the utilization of melatonin-mediated ARF biogel(AM gel)promoted diabetic wound regeneration at a more rapid healing rate.RNA-Seq analysis showed that AM gel treatment could restore more favorable immune tissue homeostasis with unique inflammatory patterning as a result of the diminished intensity of acute and chronic inflammation.Currently,AM gel could be a novel and promising therapeutic strategy for diabetic wounds in clinical practice through favorable immune homeostatic reconstructions in the tissue microenvironment and proper posttraumatic inflammation patterning.

关 键 词：autologous regeneration factors wound healing HOMEOSTASIS tissue microenvironment inflammation patterning 

分 类 号：R587.1[医药卫生—内分泌]