Nitric oxide-releasing polyurethane/S-nitrosated keratin mats for accelerating wound healing  

作　　者：Jie Dou Rong Yang Xingxing Jin Pengfei Li Xiao Han Lijuan Wang Bo Chi Jian Shen Jiang Yuan 

机构地区：[1]Jiangsu Collaborative Innovation Center of Biomedical Functional Materials,Jiangsu Key Laboratory of Bio-functional Materials,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,P.R.China [2]State Key Laboratory of Materials-Oriented Chemical Engineering,College of Food Science and Light Industry,Nanjing Tech University,Nanjing 211816,P.R.China

出　　处：《Regenerative Biomaterials》2022年第1期294-302,共9页再生生物材料（英文版）

基　　金：support from Jiangsu Higher Education Institutions(19KJA310001,PAPD).

摘　　要：Nitric oxide(NO)plays an important role in wound healing,due to its ability to contract wound surfaces,dilate blood vessels,participate in inflammation as well as promote collagen synthesis,angiogenesis and fibroblast proliferation.Herein,keratin was first nitrosated to afford S-nitrosated keratin(KSNO).As a NO donor,KSNO was then co-electrospun with polyurethane(PU).These as-spun PU/KSNO biocomposite mats could release NO sustainably for 72 h,matching the renewal time of the wound dressing.Moreover,these mats exhibited excellent cytocompatibility with good cell adhesion and cell migration.Further,the biocomposite mats exhibited antibacterial properties without inducing severe inflammatory responses.The wound repair in vivo demonstrated that these mats accelerated wound healing by promoting tissue formation,collagen deposition,cell migration,re-epithelialization and angiogenesis.Overall,PU/KSNO mats may be promising candidates for wound dressing.

关 键 词：KERATIN nitric oxide wound dressing electrospinning BIOCOMPOSITE 

分 类 号：R318[医药卫生—生物医学工程]