Rational design of hydrogels for immunomodulation  

作　　者：Wenhuan Bu Yuanhao Wu Amir M.Ghaemmaghami Hongchen Sun Alvaro Mata 

机构地区：[1]Liaoning Provincial Key Laboratory of Oral Diseases,School of Stomatology,China Medical University,No.117,Nanjing North Street,Heping District,Shenyang 110001,China [2]Department of Dental Materials,School of Stomatology,China Medical University,No.117,Nanjing North Street,Heping District,Shenyang 110001,China [3]Department of Center Laboratory,School of Stomatology,China Medical University,No.117,Nanjing North Street,Heping District,Shenyang 110001,China [4]School of Pharmacy,University of Nottingham,University Park,Nottingham NG72RD,UK [5]Biodiscovery Institute,University of Nottingham,University Park,Nottingham NG72RD,UK [6]Division of Immunology,School of Life Sciences,University of Nottingham,University Park,Nottingham NG72RD,UK [7]Terasaki Institute for Biomedical Innovation,1018 Westwood Blvd,Los Angeles,CA 90024,USA [8]Department of Chemical and Environmental Engineering,University of Nottingham,University Park,Nottingham NG72RD,UK

出　　处：《Regenerative Biomaterials》2022年第1期979-1000,共22页再生生物材料（英文版）

基　　金：supported by the ERC Proof-of-Concept Grant(MINGRAFT),the AO Foundation Grant(AOCMF-17-19M);the Medical Research Council(UK Regenerative Medicine Platform Acellular/Smart Materials-3D Architecture,MR/R015651/1);the National Natural Science Foundation of China(81870741,82001023),China Postdoctoral Science Foundation(2019M661177);Natural Science Foundation of Liaoning Province(2020-MS-154);China Scholarship Council([2020]50).

摘　　要：The immune system protects organisms against endogenous and exogenous harm and plays a key role in tissue development,repair and regeneration.Traditional immunomodulatory biologics exhibit limitations including degradation by enzymes,short half-life and lack of targeting ability.Encapsulating or binding these biologics within biomaterials is an effective way to address these problems.Hydrogels are promising immunomodulatory materials because of their prominent biocompatibility,tuneability and versatility.However,to take advantage of these opportunities and optimize material performance,it is important to more specifically elucidate,and leverage on,how hydrogels affect and control the immune response.Here,we summarize how key physical and chemical properties of hydrogels affect the immune response.We first provide an overview of underlying steps of the host immune response upon exposure to biomaterials.Then,we discuss recent advances in immunomodulatory strategies where hydrogels play a key role through(i)physical properties including dimensionality,stiffness,porosity and topography;(ii)chemical properties including wettability,electric property and molecular presentation;and(iii)the delivery of bioactive molecules via chemical or physical cues.Thus,this review aims to build a conceptual and practical toolkit for the design of immune-instructive hydrogels capable of modulating the host immune response.

关 键 词：HYDROGELS IMMUNOMODULATION physical properties chemical properties 

分 类 号：TQ427.26[化学工程]