Hyaluronic acid association with bacterial,fungal and viral infections:Can hyaluronic acid be used as an antimicrobial polymer for biomedical and pharmaceutical applications?  

作　　者：Fernanda Zamboni Chun Kwok Wong Maurice N.Collins 

机构地区：[1]Bernal Institute,School of Engineering,University of Limerick,Ireland [2]Health Research Institute,University of Limerick,Ireland [3]Department of Chemical Pathology,The Chinese University of Hong Kong,Hong Kong Special Administrative Region

出　　处：《Bioactive Materials》2023年第1期458-473,共16页生物活性材料（英文）

基　　金：would like to thank the funding provided by the Irish Research Council through the IRC Postdoctoral Fellowship(GOIPG/2021/75).

摘　　要：The relationships between hyaluronic acid(HA)and pathological microorganisms incite new understandings on microbial infection,tissue penetration,disease progression and lastly,potential treatments.These understandings are important for the advancement of next generation antimicrobial therapeutical strategies for the control of healthcare-associated infections.Herein,this review will focus on the interplay between HA,bacteria,fungi,and viruses.This review will also comprehensively detail and discuss the antimicrobial activity displayed by various HA molecular weights for a variety of biomedical and pharmaceutical applications,including microbiology,pharmaceutics,and tissue engineering.

关 键 词：Hyaluronic acid HYALURONIDASE VIRULENCE Antibacterial ANTIFUNGAL ANTIVIRAL 

分 类 号：R318[医药卫生—生物医学工程]