supported by the National Natural Science Foundation of China(Nos.32273133,31970492).
Black rockfish(Sebastes schlegelii)has evolved viviparous reproduction mode.Different from the oviparous fishes,the spermatozoa of black rockfish are stored on the surface of ovarian follicle for over four months unti...
financially supported by the National Key Research and Development Program of China(No.2021YFC2100900);the National Natural Science Foundation of China(No.32171261);the Taishan Industry Leading Talent of Shandong Province(No.tscx202211017);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX23_2575).
Hyaluronan(HA),a natural high molecular weight polysaccharide,has extensive applications in cosmetology and medical treatment.Hyaluronan-degrading enzymes(Hyals)act as molecular scissors that cleave HA by breaking the...
supported by the National Natural Science Foundation of China(32000058);the Jiangsu Province Natural Science Fund for Distinguished Young Scholars(BK20200025);the National Key Research and Development Program of China(2021YFC2103100).
Leech hyaluronidase(LHyal)is a hyperactive hyaluronic acid(HA)hydrolase that belongs to the hyaluronoglu-curonidase family.Traditionally,LHyal is extracted from the heads of leeches,but the recent development of the P...
financially supported by the National Natu-ral Science Foundation of China (Nos.32071334,51825302 and 21734002);the Natural Science Foundation of Chongqing (Nos.cstc2021jcyj-cxttX0002 and cstc2019jscx-msxmX0160).
Bacterial infection and insufficient osseointegration are critical factors affecting the long-term success of titanium-based implants.Unfortunately,the direct application of antibiotic on Ti implants easily leads to p...
supported by the Key Areas Research and Development Program of Guangdong Province(No.2019B020204002);the Key Areas Research and Development Program of Guangzhou(No.202007020006);the Fundamental Research Funds for the Central Universities(No.21620356);the Natural Science Foundation of Guangdong Province(No.2021A1515012525);the Science and Technology Foundation of Guangdong(No.2021A0505080011).
Tumor hypoxia is the pivotal factor limiting the therapeutic efficacy of photodynamic therapy(PDT),and can be partly improved by either the oxygen economizing or the oxygen supplementation strategies.Nevertheless,the ...
would like to thank the funding provided by the Irish Research Council through the IRC Postdoctoral Fellowship(GOIPG/2021/75).
The relationships between hyaluronic acid(HA)and pathological microorganisms incite new understandings on microbial infection,tissue penetration,disease progression and lastly,potential treatments.These understandings...
The current work presents the development of a nanostructured lipid carrier(NLC)as a colloidal encapsulation and controlled release system for bioactiveγ-oryzanol(GO)from rice bran oil.GO-loaded NLC(GO-NLC)were prepa...
supported by the KRIBB Research Initiative Program(KGM4252122);the National Research Foundation(2018M2A9Hl078340);the National Research Foundation of Korea Grant funded by the Korean Government(NRF-2020R111A3072358).
Glycosylphosphatidylinositol-anchored sperm hyaluronidases have long been believed to assist in sperm penetration through the cumulus-oocyte complex(COC);however,their role in mammalian fertilization remains unclear.P...
Introduction: Hyaluronidases are a group of enzymes that permit greater diffusion of fluid through the tissues. These enzymes have the ability to reduce the viscosity of hyaluronic acid and increase cellular membrane ...
This work was supported by the National Natural Science Foundation of China(81761148028,21773026,82001830);the National Key R&D Program(2017YFE0196200);the Science and Technology Commission of Shanghai Municipality(19XD1400100,19410740-200,20520710300);and the Shanghai Education Commission through the Shanghai Leading Talents Program.
The condensed tumor extracellular matrix(ECM)consisting of cross-linked hyaluronic acid(HA)is one of the key factors that result in the aberrant tumor microenvironment and severely impair drug delivery and tumor penet...