辅助生殖技术治疗不孕妇女后自然流产绒毛染色体异常影响因素分析  

Analysis of the influence factors of chromosome abnormality in chorionic villus alfter spontaneous abortion of infertile pa-tients with assisted reproductive technology

作　　者：唐苗苗 孙超 李楠 刘晶静 王海静 TANG Miaomiao;SUN Chao;LI Nan;LIU Jingjing;WANG Haijing(The Third People's Hospital of Baoji,Shaanxi Province,721000;The First Affiliated Hospital of Xi'an J iaotong University,Xian,Shaanxi Province;The Affiliated Hospital of Shaanxi University of traditional Chinese medicine,Xianyang,Shaanxi Province)

机构地区：[1]陕西省宝鸡市第三人民医院,721000 [2]西安交通大学第一附属医院 [3]陕西中医药大学附属医院

出　　处：《中国计划生育学杂志》2023年第4期877-879,共3页Chinese Journal of Family Planning

摘　　要：目的:分析接受辅助生殖技术(ART)治疗的不孕患者发生自然流产绒毛染色体异常的影响因素。方法:收集2018年4月-2020年3月宝鸡市第三人民医院、西安交通大学第一附属医院以及陕西中医药大学附属医院收治的接受ART治疗后自然流产的不孕患者113例,根据绒毛组织染色体G显带核型分析分为异常组(n=61)和正常组(n=52)。分析绒毛染色体异常发生及类型,分析绒毛染色体异常危险因素。结果:113例中染色体异常61例,发生率为54.0%,其中三倍体占比最高(59.0%);染色体异常发生率,36~50岁组大于年龄20~35岁组、自然流产≥3次者高于2次者(均P<0.05),支原体感染、ART前宫腔操作次数及胚胎移植方法与染色体异常发生率未见差异(P>0.05);高龄、自然流产≥3次是引起ART后自然流产绒毛染色体异常的因素(P<0.05)。结论:高龄、自然流产次数多是ART治疗后自然流产绒毛染色体异常的危险因素。Objective:To analyze the factors of chromosome abnormality in chorionic villus after spontaneous abortion of infertile patients with assisted reproductive technology(ART).Methods:From April 2018 to March 2020,113 in-fertile patients with spontaneous abortion after ART treatment were collected.The patients were divided into study group(n=61)and control group(n=52)according to the results of G-banding karyotype analysis of chorionic villus tissue.The occurrence and type of chromosome abnormality in chorionic vllus tissue,and the risk factors of the chro-mosome abnormality of the patients were analyzed.Results:Among 113 patients,there were 61 cases with abnormal chromosome,and the incidence was 54.0%。Among them,the triploid of chromosome accounted for the highest pro-portion(59.0%).The incidence of chromosome abnormality of the patients with 36-50 years old was significantly high-er than that of the patients with 20-35 years old,and which of the patients with spontaneous abortion≥3 times was significantly higher than that of the patients with spontaneous abortion2 times(all P<0.05).There was no significant difference in the incidence of chromosome abnormality between the patients with and without mycoplasma infection,a-mong the patients with different times of uterine operation before ART,or among the patients with different methods of embryo transfer(P>0.05).The advanced age and the spontaneous abortion≥3 times of the patients with ART were the factors of their chromosome abnormality in villus tissues after spontaneous abortion(P<<0.05).Conclusion:The advanced age and the times of spontaneous abortion of the patients with ART are the risk factors of their chromo-some abnormality in villus tissues.

关 键 词：不孕 辅助生殖技术 自然流产 绒毛 染色体异常 影响因素 

分 类 号：R714.8[医药卫生—妇产科学]