基于T_(1)WI增强的MR纹理分析评价胶质母细胞瘤MGMT启动子甲基化的研究  

Study of evaluating MGMT promoter methylation in glioblastoma based on T_(1)WI enhanced MR texture analysis

作　　者：王汝佳 马梦华 王海平 孙静华 杨越清 闫赛克 WANG Ru-jia;MA Meng-hua;WANG Hai-ping;SUN Jing-hua;YANG Yue-qing;YAN Sai-ke(Department of Radiology,Tangshan Gongren Hospital,Hebei 063000,China)

机构地区：[1]唐山市工人医院影像科,河北唐山063000

出　　处：《影像诊断与介入放射学》2023年第2期83-88,共6页Diagnostic Imaging & Interventional Radiology

基　　金：2021年度河北省医学科学研究课题计划(20210447)。

摘　　要：目的本研究主要是分析O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)启动子甲基化状态与胶质母细胞瘤(GBM)磁共振纹理特征的相关性。方法收集经本院病理诊断为GBM的患者128例,所有患者术前均行磁共振平扫及增强检查。利用3D Slicer软件提取4方面磁共振纹理特征,包括一阶数据、形态和形状、纹理:灰度共生矩阵、纹理:灰度运行长度矩阵。采用χ^(2)检验分析MGMT启动子甲基化与GBM磁共振特征的关系;采用独立样本t检验以及Mann-Whitney U检验,分析MGMT启动子甲基化与磁共振纹理特征的关系。结果MGMT启动子甲基化GBM与MGMT启动子未甲基化GBM的磁共振纹理特征相比较,有7种磁共振纹理特征差异显著(P<0.05),分别是能量(P=0.033)、熵(P=0.032)、一致性(P=0.030)、自相关(P=0.035)、方差:灰度共生矩阵(P=0.031)、灰度不均匀性(P=0.029)、群集阴影(P=0.032)。结论MGMT启动子甲基化GBM与MGMT启动子未甲基化GBM的磁共振纹理特征相比较,有7种磁共振纹理特征可以作为预测MGMT启动子甲基化GBM预后的独立因素。Objective The present study is aim to analyze the correlation between the texture analysis on MRI with O6-methylguanine-DNA methyltransferase(MGMT)in glioblastoma.Methods A total of 128 patients with pathological confirmed glioblastomas from 2015 to 2018 in our hospital were included.All patients underwent conventional MRI and contrast-enhanced T1-weighted imaging before surgery.Using a designated multi-platform named 3D Slicer,four categories were extracted,including First-order statistics,Morphology and Shape,Texture:GLCM,Texture:GLRL.χ^(2) test was conducted to analyze MRI features and the status of MGMT promoter methylation in gliblastoma.χ^(2) test was used to analyze the correlation between MRI textural features and the status of MGMT promoter methylation in gliblastoma.Student’s t-test and Mann-Whitney U-test were conducted to analyze the association between the status of MGMT promoter methylation and MRI texture features.Results There were 7 of magnetic resonance texture features,including Energy(P=0.033),Entropy(P=0.032),Uniformity(P=0.030),Autocorrelation(P=0.035),Variance(GLCM)(P=0.031),GLN(P=0.029),Cluster Shade(P=0.032)showed statistical significance.Conclusion Seven MRI texture features may serve as independent factor for predicting the prognosis of glioblastoma patients with methylated MGMT promoters.

关 键 词：胶质母细胞瘤 O^(6)-甲基鸟嘌呤-DNA甲基转移酶启动子甲基化 磁共振成像 纹理分析 

分 类 号：R739.41[医药卫生—肿瘤] R445.2[医药卫生—临床医学]