丝切蛋白-1、磷酸化丝切蛋白-1、CD11c在鼻咽癌组织中的表达及临床意义  

Expression of Cofilin-1,phosphorylated Cofilin-1 and CD11c in nasopharyngeal carcinoma and clinical significance

作　　者：曾林梅 龙金华 金风 吴伟莉 贺晓燕 杨勇 李娟 龙萃 顾安琴 金仙槐 ZENG Linmei;LONG Jinhua;JIN Feng;WU Weili;HE Xiaoyan;YANG Yong;LI Juan;LONG Cui;GU Anqin;JIN Xianhuai(Department of Oncology,Cancer Hospital Affiliated to Guizhou Medical University,Guiyang 550008,China)

机构地区：[1]贵州医科大学附属肿瘤医院肿瘤科,贵阳550008 [2]贵州医科大学临床医学院,550025 [3]贵州医科大学附属肿瘤医院病理科,550008

出　　处：《临床肿瘤学杂志》2023年第3期218-224,共7页Chinese Clinical Oncology

基　　金：国家自然科学基金资助项目(82060555);贵州医科大学国家自然科学基金培育项目(19NSP047);基于NFκB-cGAMP-cGAS-STING通路研究树突状细胞在鼻咽癌放疗免疫致敏中的作用(财务编码I-2020-23)。

摘　　要：目的探讨丝切蛋白1(Cofilin-1)、磷酸化丝切蛋白1(p-Cofilin-1)及树突状细胞(DCs)亚群在鼻咽癌组织中的表达及与预后的关系。方法回顾性分析2011年1月至2015年12月97例鼻咽癌患者的临床资料,采用免疫组化法检测鼻咽癌组织中Cofilin-1、p-Cofilin-1及CD11c+DCs的表达情况。分析三者表达与鼻咽癌临床病理特征和预后的关系。结果97例鼻咽癌患者中,Cofilin-1低表达率为26.8%(26/97),高表达率为73.2%(71/97);p-Cofilin-1低表达率为27.8%(27/97),高表达率为72.2%(70/97)。CD11c低表达率为80.4%(78/97),高表达率为19.6%(19/97)。M分期、临床分期、治疗后转移、治疗前骨转移和治疗后出现骨转移与Cofilin-1的表达有关(P<0.05);治疗后转移和治疗后出现骨转移与p-Cofilin-1的表达有关(P<0.05);CD11c表达与鼻咽癌临床病理参数均无关(P>0.05)。Cofilin-1低表达组和高表达组1、3、5年生存率分别为84.6%、73.1%、73.1%和93.0%、61.7%、46.7%(P=0.094);低表达组和高表达组1、3、5年无远处转移生存率分别为100.0%、100.0%、100.0%和87.2%、73.3%、68.6%(P=0.002)。p-Cofilin-1低表达组和高表达组1、3、5年生存率分别为85.2%、51.9%、40.4%和92.9%、72.7%、59.3%(P=0.075);低表达组和高表达组1、3、5年无远处转移生存率分别为83.5%、53.7%、53.7%和95.1%、89.9%、85.5%(P=0.001)。CD11c低表达组和高表达组1、3、5年生存率分别为89.7%、61.3%、46.5%和94.7%、89.5%、89.5%(P=0.007);低表达组和高表达组1、3、5年无远处转移生存率分别为88.8%、80.2%、76.1%和100.0%、93.8%、87.1%(P=0.175)。结论Cofilin-1表达水平越高,肿瘤转移风险越高,无远处转移生存时间越短;p-Cofilin-1表达水平越高,肿瘤发生转移的风险越低,无远处转移生存时间越长;CD11c表达水平越高,总生存时间越长。Cofilin-1、p-Cofilin-1、CD11有望成为鼻咽癌靶向治疗和预后预测的标志物。Objective To study the expression of Cofilin-1,p-Cofilin-1 and dendritic cell(DCs)subsets in nasopharyngeal carcinoma and their relationship with prognosis.Methods The clinical data of 97 patients with nasopharyngeal carcinoma from January 2011 to December 2015 were retrospectively analyzed.The expression of Cofilin-1,p-Cofilin-1 and CD11c+DCs in nasopharyngeal carcinoma tissues was detected by immunohistochemistry.The relationship between the expression of the three proteins and the clinicopathological characteristics and prognosis of nasopharyngeal carcinoma was further analyzed.Results In 97 patients with nasopharyngeal carcinoma,the low expression rate of Cofilin-1 was 26.8%(26/97),and the high expression rate was 73.2%(71/97);The low expression rate of p-Cofilin-1 was 27.8%(27/97),and the high expression rate was 72.2%(70/97).The low expression rate of CD11c was 80.4%(78/97),and the high expression rate was 19.6%(19/97).M stage,clinical stage,metastasis after treatment,bone metastasis before and after treatment were related to the expression of Cofilin-1(P<0.05);Post-treatment metastasis and post-treatment bone metastasis were related to the expression of p-Cofilin-1(P<0.05);The expression of CD11c was not correlated with the clinicopathologic parameters of nasopharyngeal carcinoma(P>0.05).The 1-,3-,and 5-year survival rates of Cofilin-1 low expression group and high expression group were 84.6%,73.1%,73.1%and 93.0%,61.7%,46.7%,respectively(P=0.094);The 1-,3-,and 5-year survival rates without distant metastasis in the low expression group and the high expression group were 100.0%,100.0%,100.0%and 87.2%,73.3%,68.6%,respectively(P=0.002).The 1-,3-and 5-year survival rates of p-Cofilin-1 low expression group and high expression group were 85.2%,51.9%,40.4%and 92.9%,72.7%and 59.3%respectively(P=0.075);The 1-,3-,and 5-year survival rates without distant metastasis in low expression group and high expression group were 83.5%,53.7%,53.7%and 95.1%,89.9%,85.5%,respectively(P=0.001).The 1-,3-,and 5-year survival rates

关 键 词：鼻咽癌 丝切蛋白-1 磷酸化丝切蛋白-1 树突状细胞亚群 CD11C 

分 类 号：R739.63[医药卫生—肿瘤]