根治性前列腺切除手术Gleason评分升级和切缘阳性不良病理特征的影响因素  

Influencing factors of the upgrading of Gleason score and adverse pathological features of positive incisal margin after radical prostatectomy

作　　者：张国辉 李建昌 柳建军 罗帆 王帆 连湃 ZHANG Guo-hui;LI Jian-chang;LIU Jian-jun;LUO Fan;WANG Fan;LIAN Pai(Department of Urology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China)

机构地区：[1]广东医科大学附属医院泌尿外科,广东湛江524001

出　　处：《广东医科大学学报》2023年第2期220-226,共7页Journal of Guangdong Medical University

摘　　要：根治性前列腺切除术是临床上治疗局限性前列腺癌的常用手段,手术病理是后续治疗的重要依据。但是手术病理会出现Gleason评分升级和切缘阳性等不良病理情况,这两种不良病理都与不良预后相关,尤其是术后出现生化复发。了解相关的高危因素有助于制定个性化治疗方案,规避术后不良病理发生,提高患者生存质量。该文综述了根治性前列腺切除手术Gleason评分升级和切缘阳性不良病理特征的影响因素。Radical prostatectomy is a common clinical treatment for localized prostate cancer.Surgical pathology is an important basis for follow-up treatment.However,the surgical pathology can present with adverse pathologic features,including the upgrading of Gleason score and positive incisal margins,both of which are related to poor prognosis,especially postoperative biochemical recurrence.Understanding the relevant high-risk factors can help to provide optimal individualized treatment,avoid the occurrence of postoperative adverse pathology and improve the quality of life of patients.This paper reviews the influencing factor of the upgrading of Gleason score and adverse pathological features of positive incisal margin after radical prostatectomy.

关 键 词：前列腺肿瘤 根治性前列腺切除术 GLEASON评分 切缘阳性 

分 类 号：R737.25[医药卫生—肿瘤]