果胶钡凝胶胃内滞留释药系统制备与体外评价  

Preparation and In Vitro Evaluation of Dipyridamole Loaded Barium Pectin Gastric Retention Drug System

作　　者：王家玉[1] 李琳[1] 陈琳[1] WANG Jia-yu;LI Lin;CHEN Lin(Dept of Pharmacy,Women and Children's Hospital of Chongqing Medical University(Chongqing Health Center for Women and Children),Chongqing 401147,China)

机构地区：[1]重庆医科大学附属妇女儿童医院(重庆市妇幼保健院)药学部,重庆401147

出　　处：《食品与药品》2023年第2期188-191,共4页Food and Drug

基　　金：重庆市渝中区科技局基础与前沿课题(编号:20180157);重庆市妇幼保健院院级科研课题(编号:2020YJQN04)。

摘　　要：目的 考察双嘧达莫果胶钡胃漂浮凝胶微丸的漂浮性、溶胀率及释药行为。方法 以果胶为微丸骨架材料,氯化钡为交联材料,碳酸氢钠为产气试剂,选取Eudragit L100和Eudragit RLPO作为固体分散体载体材料,以溶剂法制备双嘧达莫固体分散体胃漂浮微丸。以人工胃液为介质,考察微丸的外观、粒径、溶胀率、漂浮率和体外释放度。结果 载双嘧达莫固体分散体胃漂浮凝胶微丸持续9 h漂浮率超过94%,药物累积释放时间超过6 h,6 h的药物累积释放率超过70%。结论 本文制备的双嘧达莫固体分散体胃漂浮微丸可在人工模拟胃液中持续漂浮并缓慢释放药物。Objective To investigate the floatability,swelling rate and interpretation behavior of the dipyridamole loaded barium pectin gel pellets.Methods Using pectin as the skeleton material,barium chloride as the cross-linking material,sodium bicarbonate as the gas generating agent,Eudragit L100 and Eudragit RLPO as solid dispersion carrier materials,dipyridamole loaded solid dispersion gastric floating pellets were prepared by solvent method.Using artificial gastric juice as medium,the appearance,particle size,swelling rate,floating rate,and in vitro release of the pellets were investigated.Results More than 94 % of the gastric floating pellets kept floating in 9 h.The cumulative drug release time exceeded 6 h,and the accumulative release rate of dipyridamole exceeded 70 % after 6 h.Conclusion The dipyridamole solid dispersion loaded gastric floating pellets prepared in this paper can continuously float and slowly release drugs in artificial gastric juice.

关 键 词：果胶 胃靶向 固体分散体 钡离子 胃漂浮 

分 类 号：R943[医药卫生—药剂学]