中医药调控mTOR信号通路治疗阿尔茨海默病的研究进展  

Research progress of TCM regulating mTOR signaling pathway in the treatment of Alzheimer's disease

作　　者：刘长宁 张立娟[2] 侯翰如 管秀菊 朱玲慧 王康锋[2] LIU Chang-ning;ZHANG Li-juan;HOU Han-ru;GUAN Xiu-ju;ZHU Ling-hui;WANG Kang-feng(Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China;Shanxian Hospital of Traditional Chinese Medicine,Heze 274300,Shandong,China)

机构地区：[1]山东中医药大学,山东济南250014 [2]山东中医药大学附属医院,山东济南250014 [3]单县中医医院,山东菏泽274300

出　　处：《海南医学院学报》2023年第8期628-634,共7页Journal of Hainan Medical University

基　　金：国家自然科学基金青年基金(81303028);山东省科技发展计划(2014GSF119038);济南市科技创新发展计划(202019027、201805083);山东省中医药科技发展计划(2017-040;2019-0107;2019-0094;2017-037);山东中医药大学附属医院首批青年科研创新团队项目。

摘　　要：阿尔茨海默病(alzheimer’s disease,AD)是一种中枢神经系统退行性病变。AD的发病机制复杂多样,其发生发展是多种因素共同作用的结果,多项研究表明mTOR信号通路与AD密切相关。近年来,人们在探索治疗AD的相关方法和药物的过程中,越来越多的研究发现中药复方以及中药单体可作用于mTOR信号通路以改善AD患者的症状。本文将对近年来中医药基于mTOR信号通路在阿尔茨海默病中的相关作用机制以及有关治疗进行综述,为AD的防治提供参考并拓展思维。Alzheimer's disease(AD)is a degenerative disease of the central nervous system.The pathogenesis of AD is complex and diverse,and its occurrence and development is the result of the interaction of multiple factors.A number of studies have shown that mTOR signaling pathway is closely related to AD.In recent years,people in exploring relevant methods for the treatment of AD and the process of drugs,more and more studies have found that traditional Chinese medicine compound traditional Chinese medicine monomer,and can be applied to mTOR signaling pathway to improve symptoms in patients with AD.This paper will review the mechanism of action and treatment of TCM in Alzheimer's disease based on mTOR signaling pathway in recent years,so as to provide reference and expand thinking for the prevention and treatment of AD.

关 键 词：阿尔茨海默病 MTOR 信号通路 中医药 研究进展 

分 类 号：R277.7[医药卫生—中医学]