Rab40家族在肝癌中的表达及临床意义  

Expression and clinical significance of Rab40 family in liver cancer

作　　者：张文哲 孙蕾民 ZHANG Wenzhe;SUN Leimin(the Fourth Affiliated Hospital,School of Medicine,Zhejiang University,Jinhua 322000;Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310000,China)

机构地区：[1]浙江大学医学院附属第四医院,浙江金华322000 [2]浙江大学医学院附属邵逸夫医院,浙江杭州310000

出　　处：《临床医学研究与实践》2023年第13期9-12,共4页Clinical Research and Practice

摘　　要：目的探讨Rab40家族在肝癌中的表达及临床意义。方法收集TIMER2.0数据库和The Human Protein Atlas数据库中肝癌数据集,分析Rab40家族在肝癌患者中的表达水平,并分析其表达与患者临床病理资料、肿瘤微环境免疫细胞浸润的关系;收集Kaplan-Meier Plotter数据库中肝癌数据集,分析Rab40b和Rab40c的表达水平与肝癌患者预后的关系。结果肝癌组织中的Rab40a、Rab40al、Rab40b和Rab40c表达水平显著高于癌旁组织,差异具有统计学意义(P<0.05)。Rab40c高表达与肝癌患者TNM分期可能存在相关性(P=0.064)。Rab40b、Rab40c高表达肝癌患者的总生存期(OS)、无复发生存期(RFS)短于Rab40b、Rab40c低表达肝癌患者,差异具有统计学意义(P<0.05)。肝癌组织中Rab40b的表达水平与肿瘤微环境的B细胞和CD8^(+)T细胞无关(P>0.05),而与CD4^(+)T细胞、巨噬细胞、中性粒细胞和树突状细胞密切相关,差异具有统计学意义(P<0.05)。肝癌组织中Rab40c的表达水平与肿瘤微环境的B细胞、CD8^(+)T细胞、CD4^(+)T细胞、巨噬细胞、中性粒细胞和树突状细胞密切相关,差异具有统计学意义(P<0.05)。结论Rab40家族在肝癌中高表达,尤其是Rab40b和Rab40c,通过影响肿瘤微环境中的免疫细胞促进肝癌的发生、发展,可作为肝癌治疗和预后的潜在生物标志物。Objective To explore the expression and clinical significance of Rab40 family in liver cancer.Methods The data sets of liver cancer in TIMER2.0 database and The Human Protein Atlas database were collected,the expression level of Rab40 family in patients with liver cancer was analyzed,and the relationship between its expression and clinicopathological data and tumor microenvironment immune cell infiltration was analyzed.The data set of liver cancer in the Kaplan-Meier Plotter database was collected to analyze the relationship between the expression levels of Rab40b and Rab40c and the prognosis of liver cancer patients.Results The expression levels of Rab40a,Rab40al,Rab40b and Rab40c in liver cancer tissues were significantly higher than those in cancer-adjacent tissues,and the differences were statistically significant(P<0.05).The high expression of Rab40c might be correlated with TNM staging of liver cancer patients(P=0.064).The overall survival(OS)and recurrence-free survival(RFS)of liver cancer patients with high expression of Rab40b and Rab40c were shorter than those with low expression of Rab40b and Rab40c,and the differences were statistically significant(P<0.05).The expression level of Rab40b in liver cancer tissues was not related to B cell and CD8^(+)T cell in the tumor microenvironment(P>0.05),while it was closely related to CD4^(+)T cell,macrophage,neutrophil and dendritic cell,and the differences were statistically significant(P<0.05).The expression level of Rab40c in liver cancer was closely related to B cell,CD8^(+)T cell,CD4^(+)T cell,macrophage,neutrophil and dendritic cell in the tumor microenvironment,and the differences were statistically significant(P<0.05).Conclusion Rab40 family is highly expressed in liver cancer,especially Rab40b and Rab40c,which promote the occurrence and development of liver cancer by affecting immune cells in the tumor microenvironment,and can be used as potential biomarkers for the treatment and prognosis of liver cancer.

关 键 词：肝癌 Rab40a Rab40al Rab40b Rab40c 

分 类 号：R735.7[医药卫生—肿瘤]