青少年抑郁症患者海马磁共振成像研究进展  

MRI advances of hippocampus in adolescents with depression

作　　者：冯若涵 卓丽华[1] 李宏伟 欧阳心芹 龙拥军[1] 黄晓琦[2,3] FENG Ruohan;ZHUO Lihua;LI Hongwei;OUYANG Xinqin;LONG Yongjun;HUANG Xiaoqi(Department of Radiology,the Third Hospital of Mianyang,Sichuan Mental Health Center,Mianyang 621000,China;Huaxi MR Research Center(HMRRC),West China Hospital,Sichuan University,Chengdu 610041,China;Functional and Molecular Imaging Key Laboratory of Sichuan Province,Chengdu 610041,China)

机构地区：[1]绵阳市第三人民医院(四川省精神卫生中心)放射科,绵阳621000 [2]四川大学华西医院磁共振研究中心,成都610041 [3]功能与分子影像四川省重点实验室,成都610041

出　　处：《磁共振成像》2023年第4期120-125,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：四川省青年科技基金(编号:2017JQ0001);四川应用心理学研究中心项目(编号:CSXL-203005、CSXL-203006)。

摘　　要：抑郁症是影响青少年身心健康以及致残和死亡的主要原因。关于抑郁症的发病机制目前仍不清楚,既往研究发现海马在抑郁症的发病机制中起着重要作用,海马成为了近年来很多抑郁症相关神经影像学研究的焦点,但是对于青少年的研究相对较少。本研究通过对近年来青少年抑郁症患者海马的磁共振结构成像、功能成像、波谱成像等进行简要综述发现,青少年抑郁症患者存在海马结构、功能、代谢的异常,并且这些异常改变与早期不良经历和压力事件高度相关,这可能是这些风险因素导致抑郁症的一种神经生物学机制。未来我们需要更多纵向和大样本研究来进一步验证之前的这些发现,并且需要更多关注环境等风险因素与大脑改变之间的关系。本综述通过总结青少年抑郁症患者海马研究现状及不足,为将来的研究提供参考方向,为进一步探索青少年抑郁症的发病机制提供帮助。Depression is the main cause of disability and death in adolescents.The pathogenesis of depression is still unclear.Researchers have suggested that the hippocampus plays a critical role in depression pathogenesis.Many neuroimaging studies related to depression have targeted the hippocampus in recent years,but few studies on adolescents have been conducted.The advanced MRI methods of hippocampus in adolescents with depression are reviewed in this article,such as structural and functional MRI,magnetic resonance spectroscopy,and findings of structure,function,and metabolism abnormalities associated with early adverse experiences and stressful events.This may be a neurobiological mechanism behind depression caused by these risk factors.More longitudinal and large-scale studies are needed to further verify these previous findings,and the relationship between risk factors such as the environment and brain changes needs to be further explored.This review summarized current status and shortcomings of research on the hippocampus of adolescents with depression in order to provide a reference direction for future research.

关 键 词：抑郁症 青少年 海马 磁共振成像 磁共振结构成像 磁共振功能成像 磁共振波谱 弥散张量成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749[医药卫生—诊断学]