转录激活因子参与器官纤维化的研究进展  

Progress in activating transcription factors involved in organ fibrosis

作　　者：杨钊 齐婧姝 平大冰 孙鑫 陶艳艳 刘成海 彭渊[1] YANG Zhao;QI Jingshu;PING Dabing;SUN Xin;TAO Yanyan;LIU Chenghai;PENG Yuan(Institute of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shang-hai 201203,China;Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Shanghai 201203,China;Key Laboratory of Liver and Kidney Diseases,Ministry of Education,Shanghai 201203,China;Shanghai Innovation Center of TCM health Service,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院肝病研究所,上海201203 [2]上海市中医临床重点实验室,上海201203 [3]肝肾疾病病证教育部重点实验室,上海201203 [4]上海中医健康服务协同创新中心,上海201203

出　　处：《中国病理生理杂志》2023年第4期739-746,共8页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81730109,No.81874363,No.82174057);科技部“重大新药创制”科技重大专项(No.2019ZX09201001);上海市科委科技支撑项目(No.19401901500)。

摘　　要：纤维化是多种疾病共同的病理环节,可影响任何器官,常导致组织器官实质细胞减少和结缔组织增生,引起进行性组织结构破坏和器官功能障碍[1-2]。纤维化是一个动态的、具有可逆性的病理过程,涉及多种细胞与信号转导间交联。转录激活因子(activating transcription factors,ATFs)是信号转导网络的关键枢纽,串联多种细胞信号,涉及内质网应激(endoplasmic reticulum stress,ERS)与靶细胞氧化应激、细胞增殖/凋亡、线粒体损伤及自噬等多种病理过程,可调节细胞功能,并影响疾病转归。目前对于ATFs在器官纤维化疾病中的表达和功能的报道较为零散,其作用机制尚不明确,本文将对ATFs的分类与特征,与器官纤维化的相关作用机制进行综述。Organ fibrosis was a common pathological change in a variety of chronic diseases,which was characterized by the increase of fibrous tissue and the decrease of parenchymal cells in tissues.Organ failure caused by organ fibrosis in the kidney,heart,lungs,liver,and other parenchymal organs raised the death and disability rates of patients.Currently,organ fibrosis incidence rates and associated medical costs have been rising yearly.Activating transcription factors(ATFs)were engaged in a variety of pathogenic processes,including as endoplasmic reticulum stress,mitochondrial damage,oxidative stress,cell proliferation,apoptosis,and autophagy,which were crucial in regulating cell function and disease development.Organ fibrosis has been shown to be closely associated to the activation of ATFs.As a result,blocking the aberrant activation of ATFs might be a possible therapeutic target for treating organ fibrosis.This article summarized the classification of ATFs and the research progress of ATFs involved in the signal pathways related to multiple organ fibrosis.

关 键 词：转录激活因子 器官纤维化 内质网应激 细胞外基质 

分 类 号：R363[医药卫生—病理学]