埃索美拉唑与奥美拉唑治疗非甾体类抗炎药致老年上消化道出血的效果比较  

Comparison on the Effects of Esomeprazole and Omeprazole in the Treatment of Elderly Upper Gastrointestinal Bleeding Induced by Non-Steroidal Anti-Infammatory Drugs

作　　者：盘车莲 何元增 曾凡永 PANG Chelian;HE Yuanzeng;ZENG Fanyong(Department of Gastroe nterology,Dongfeng People'sHospital,Zhongshan 528425,China)

机构地区：[1]中山市东凤人民医院消化科,广东中山528425

出　　处：《临床医学工程》2023年第4期475-476,共2页Clinical Medicine & Engineering

基　　金：中山市医学科研基金项目(2020J315)。

摘　　要：目的比较埃索美拉唑与奥美拉唑治疗非甾体类抗炎药(NSAIDs)致老年上消化道出血的临床效果。方法80例老年NSAIDs致上消化道出血患者根据用药方案的不同分为两组。在常规治疗基础上,对照组给予奥美拉唑治疗,观察组给予埃索美拉唑治疗。比较两组的治疗效果、止血时间、血红蛋白(HGB)水平及血小板(PLT)计数。结果治疗后,观察组的总有效率高于对照组,止血时间短于对照组,HGB水平及PLT计数均高于对照组(P<0.05)。结论埃索美拉唑治疗NSAIDs致老年上消化道出血的效果优于奥美拉唑,在缩短患者止血时间、提高患者HGB水平及PLT计数方面优势更为显著。Objective To compare the clinical effects of esomeprazole and omeprazole in the treatment of elderly upper gastrointestinal bleeding induced by non-steroidal anti-inflammatory drugs(NSAIDs).Methods 80 elderly patients with upper gastrointestinal bleeding induced by NSAIDs were divided into two groups according to different medication regimens.On the basis of routine treatment,the control group was treated with omeprazole,and the observation group was treated with esomeprazole.The therapeutic effect,hemostasis time,hemoglobin(HGB)level and platelet(PLT)count were compared between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control group,the hemostasis time was shorter than that of the control group,and the HGB level and PLT count were higher than those of the control group(P<0.05).Conclusions Esomeprazole has better effect than omeprazole in the treatment of elderly upper gastrointestinal bleeding induced by NSAIDs,which has more significant advantages in shortening the hemostasis time,improving the HGB level and PLT count of patients.

关 键 词：埃索美拉唑 奥美拉唑 非甾体类抗炎药 老年上消化道出血 

分 类 号：R573.2[医药卫生—消化系统]