CalliSpheres载药微球肝动脉栓塞治疗大肝癌的临床评价  

Clinical evaluation of transcatheter hepatic artery embolization using CalliSpheres drug-loaded microspheres in the treatment of large liver cancer

作　　者：邱忠华[1] 张伟伟[1] 乔元岗[1] 刘现闯 QIU Zhonghua;ZHANG Weiwei;QIAO Yuangang;LIU Xianchuang(Department of Interventional Therapy,Affiliated Hospital of Jining Medical University,Jining 272000,China)

机构地区：[1]济宁医学院附属医院介入治疗科,山东济宁272000

出　　处：《医学影像学杂志》2023年第4期577-581,共5页Journal of Medical Imaging

摘　　要：目的探讨CalliSpheres载药微球经肝动脉栓塞治疗不可切除大肝癌的近期疗效及安全性。方法选取CalliSpheres载药微球肝动脉栓塞治疗的24例不可切除大肝癌患者(病灶直径大于5.0 cm)的临床资料,采用mRESET评价标准,评价临床治疗效果。结果24例患者成功进行了经肝动脉载药微球栓塞术,术前及术后1月ALT、ALB、TBIL、CRE、WBC、PLT比较,差异无统计学意义(均P>0.05);依据mRESET标准,术后1、3、6个月的疾病缓解率ORR(CR+PR)分别为83.33%、79.17%、75.00%;疾病控制率DCR(CR+PR+SD)分别为95.83%、95.83%、83.33%。所有患者未出现肝衰竭、肝脓肿及消化道出血等严重并发症。结论CalliSpheres载药微球肝动脉栓塞治疗不可切除大肝癌近期临床效果较好,安全可行,严重不良反应少,值得在临床进一步推广应用。Objective To investigate the short-term efficacy and safety of transcatheter hepatic artery embolization using CalliSpheres microspheres in the treatment of unresectable large liver cancer.Methods 24 patients with unresectable large liver cancer(≥5 cm)who underwent transcatheter hepatic artery embolization using CalliSpheres microspheres were performed.And the tumor response was evaluated according to the modified Response Evaluation Criteria in Solid Tumors(mRESET).Results There was no significant statistical difference in ALT,ALB,TBIL,CRE,WBC and PLT indexes before operation and one month after operation.According to mRESET,the objective response rate(ORR)was 83.33%,79.17%and 75.00%at 1,3 and 6 months after operation.The disease control rates(DCR)were 95.83%,95.83%and 83.33%,respectively.There were no major complications such as liver failure,liver abscess and gastrointestinal bleeding.Conclusion Treatment of unresectable large liver cancer by transcatheter hepatic artery embolization using CalliSpheres drug-loaded microspheres is effective,safe,feasible,with few serious adverse reactions,which is worthy of further clinical application.

关 键 词：大肝癌 载药微球 肝动脉化疗栓塞 介入性 放射学 

分 类 号：R735.7[医药卫生—肿瘤] R815[医药卫生—临床医学]