溃疡性结肠炎最新发病机制的认识  

Recent advances in the pathogenesis of ulcerative colitis

作　　者：伍晓涵 刘占举(审校)[1] WU Xiaohan LIU Zhanju(Department of Gastroenterology,Shanghai Tenth People's Hospital of Tongji University,Shanghai,200072,China)

机构地区：[1]同济大学附属第十人民医院消化内科,上海200072

出　　处：《中国中西医结合消化杂志》2023年第4期237-242,共6页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：国家重点研发计划(No:2018YFC1705405)。

摘　　要：溃疡性结肠炎(ulcerative colitis,UC)是一种发病机制尚不明确的慢性、复发性炎症性疾病。全球范围内,其发病率及相关致死、致残率持续上升,造成了相当大的社会负担。明确UC发病机制对疾病预防、疾病行为评估、治疗方案选择及新药研发等至关重要。目前,多数西方学者认为遗传易感性、环境、肠黏膜免疫调节异常等因素相互作用,共同导致了UC的发生。中医则强调“五脏一体”,认为UC的发病与脾肺肝肾功能失调有关。本文将重点从以上几个方面总结中西医病机研究的新进展及其关联性,为临床诊疗及新药研发提供参考。Ulcerative colitis(UC)is a chronic recurrent inflammatory disease with unknown pathogenesis.The incidence of UC continues to rise globally,resulting in a considerable social burden due to its related mortality and disability.Therefore,identifying the pathogenesis of UC is crucial for disease prevention,disease behavior judgement,treatment options,and new drug development.Most western scholars believe that genetic susceptibility,environment,abnormal intestinal mucosal immune regulation,and other factors interact together to lead to the occurrence of UC.Traditional Chinese Medicine emphasizes the integration of the five viscera and believes that the incidence of UC is related to the dysfunction of the spleen,lung,liver,and kidney.This article will focus on the above aspects to summarize the new progress and relevance of Traditional Chinese and Western Medicine pathogenesis research to better understand the pathogenesis of UC and may provide therapeutic approaches in the management of disease and new drug research.

关 键 词：溃疡性结肠炎 发病机制 遗传 免疫调节 

分 类 号：R574.62[医药卫生—消化系统]