慢性胃炎中P1-HNF4α和CDX2的相关性及与病理资料的相关分析  

The correlation of P1⁃HNF4αand CDX2 and relevant analysis with pathological data in chronic gastritis

作　　者：王琳 褚明亮 刘杰民[3] 胡建军 曹颖[4] WANG Lin;CHU Mingliang;LIU Jiemin;HU Jianjun;CAO Ying(Department of Gastroenterology,Yancheng First People′s Hospital,Yancheng 224006,China;不详)

机构地区：[1]盐城市第一人民医院消化内科,江苏盐城224006 [2]贵州中医药大学第一附属医院检验科,贵阳550001 [3]贵州省人民医院消化内镜科,贵阳550002 [4]贵州省人民医院病理科,贵阳550002

出　　处：《实用医学杂志》2023年第7期838-843,共6页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:81560088,82060850);贵州省高层次创新型人才项目(编号:黔科合平台人才[2020]6016);贵州省科技厅基金项目(编号:黔科合J字[2015]2086号);贵州省人民医院博士基金项目(编号:GZSYBS[2017]03)。

摘　　要：目的探索P1-HNF4α、CDX2与慢性胃炎不同临床病理资料的关系及二者之间的相互关系。方法对294例慢性胃炎标本进行CDX2、P1-HNF4α免疫组化染色,结合慢性胃炎的不同临床病理资料进行分析。结果CDX2和P1-HNF4α蛋白表达阳性率和表达强度,在肠化生慢性胃炎组织中要高于非肠化生组织(均P<0.001)。在非肠化生组织,P1-HNF4α的表达强度和慢性胃炎的不同严重程度呈正相关(r_(s)=0.366,P<0.001)。141例^(14)C-尿素呼气试验结果显示男性HP感染阳性率明显高于女性(P=0.02)。在非肠化生标本组,CDX2的表达强度在HP感染阳性组均要高于HP感染阴性组(P=0.017)。在轻、中、重不同程度慢性胃炎组织中,CDX2和P1-HNF4α二者之间的表达强度都呈现正相关关系(均r_(s)>0.5,均P<0.001)。按年龄分组,CDX2的表达在≥40岁年龄组,阳性率高于<40岁年龄组(P=0.026)。按性别分组,CDX2的表达强度在男性组中要高于女性组(P=0.023)。按部位分组,CDX2和P1-HNF4α的阳性率在幽门部+胃角部最高,其他部位(贲门部+胃底部+胃体部)较低(均P<0.001)。除此之外,CDX2和P1-HNF4α的表达强度在幽门部+胃角部均高于其他部位(均P<0.05)。结论在慢性胃炎的部分临床病理特征中,P1-HNF4α与CDX2的表达具有相同的共性,且二者之间存在正相关关系,因此推测二者在慢性胃炎发生发展过程中可能共同发挥着重要作用。Objective To explore the relationship between P1⁃HNF4α,CDX2 and the different clinical and pathological data of chronic gastritis.Methods 294 chronic gastritis samples were stained with CDX2 and P1⁃HNF4αand analyzed with different clinical and pathological data of chronic gastritis.Results In the intestinal metaplasia group,the total positive rate and expression intensity of CDX2 and P1⁃HNF4αwere higher than those in the nonintestinal metaplasia group(all P<0.001).In the non⁃intestinal metaplasia group,the expression intensity of P1⁃HNF4αexpression and the severity of chronic gastritis were positively correlated(r_(s)=0.366,P<0.001).141 cases of Carbon⁃14 urea breath test showed that the positive rate of HP infection in men was significantly higher than that in women(P=0.02).In the non⁃intestinal metaplasia group,the expression intensity of CDX2 was higher in the H.pylori positive group than in the H.pylori negative group(P=0.017).In different degrees of chronic gastritis,the expression intensity between CDX2 and P1⁃HNF4αshowed a positive correlation(all rs>0.5,all P<0.001).By age group,the total positive rate of CDX2 was higher in≥40 years old group(P=0.026).By sex group,CDX2 expression intensity was higher in male than in female group(P=0.023).By site group,the total positive rate of CDX2 and P1⁃HNF4αwas highest in the pylorus and gastric corner,while the other sites(cardia+gastric base+gastric body)were relatively lower(both P<0.001).In addition,the expression intensity of CDX2 and P1⁃HNF4αwas higher in the pyloric and gastric corners than in the other sites(both P<0.05).Conclusion In some clinicopathological features of chronic gastritis,the expression of P1⁃HNF4αand CDX2 have the same commonness,and there is a positive correlation between P1⁃HNF4αand CDX2.It is speculated that they may both play an important role in the development of chronic gastritis.

关 键 词：慢性胃炎 CDX2 P1-HNF4α 

分 类 号：R573.3[医药卫生—消化系统]