细胞致死性膨胀毒素损伤宿主防御机制研究进展  

Cytolethal distending toxin injures host defense mechanism

作　　者：宗萱 李晓飞 任方哲[1] 焦新安 黄金林[1,3] ZONG Xuan;LI Xiaofei;REN Fangzhe;JIAO Xin’an;HUANG Jinlin(Jiangsu Key Laboratory of Zoonosis,Yangzhou University,Yangzhou 225009,Jiangsu,China;Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou 225009,Jiangsu,China;Key Laboratory of Prevention and Control of Biological Hazard Factors(Animal Origin)for Agrifood Safety and Quality,Ministry of Agriculture and Rural Affairs,Yangzhou 225009,Jiangsu,China)

机构地区：[1]扬州大学江苏省人兽共患病学重点实验室,江苏扬州225009 [2]江苏高校动物重要疫病与人兽共患病防控协同创新中心,江苏扬州225009 [3]农业农村部农产品质量安全生物性危害因子(动物源)控制重点实验室,江苏扬州225009

出　　处：《微生物学报》2023年第4期1404-1410,共7页Acta Microbiologica Sinica

基　　金：国家自然科学基金(32172939,31872493);山东省泰山产业领军人才项目(tscy20190113);扬州大学兽医学学科特区学科交叉课题支持项目(yzuxk202003)。

摘　　要：细胞致死性膨胀毒素(cytolethal distending toxin,CDT)属于AB_(2)毒素,由多种革兰氏阴性菌产生。CDT是第一种被描述的细菌基因毒素,编码3种多肽:CDTA、CDTB和CDTC。CdtB是活性部分,有损伤多种细胞类型的能力。CDT具有一种新的分子作用模式,会干扰真核细胞周期的进展,从而导致G2/M停滞和细胞凋亡,该作用机制针对细胞,而且现阶段对于CDT的研究更多也是细胞层面,但是CDT作为毒力因子最终作用是损伤宿主造成疾病。但目前对CDT与宿主相互作用的分子机制了解尚不清晰。本文对细胞致死性膨胀毒素作为毒力因子从损伤上皮屏障、适应性免疫以及促进炎症反应三方面来综合阐述其对宿主防御机制途径的损伤,以期了解其致病机制以及为其临床治疗提供理论依据和新思路。Cytolethal distending toxin(CDT)is an AB2 toxin produced by a variety of Gram-negative bacteria.It was the first bacterial genotoxin described,encoding three polypeptides:CDTA,CDTB,and CDTC.CdtB is the active moiety that has the ability to damage multiple cell types.CDT has a new molecular mode of action,which can interfere with the progress of eukaryotic cell cycle,resulting in G2/M arrest and apoptosis.Such mechanism of action targets cells,and the available studies of CDT concentrate on the cellular level.However,CDT,as a virulence factor,ultimately causes pathogenic damage to the host,and the molecular mechanism of CDT-host interaction remains unclear.This paper comprehensively expounded the damage of CDT as a virulence factor to the host defense mechanism from three aspects,including damage to the epithelial barrier,acquired immunity,and promotion of inflammatory response,aiming to reveal the pathogenic mechanism of CDT and provide a theoretical basis and new ideas for clinical treatment.

关 键 词：细胞致死性膨胀毒素 细胞膨胀 毒力因子 损伤机制 

分 类 号：R363[医药卫生—病理学]