肿瘤电场治疗联合同步放疗治疗胶质母细胞瘤研究进展  

Research progress on tumor treating fields combined with radiation therapy in the treatment of glioblastoma

作　　者：乔俏[1] 肖慧玉 李光[1] Qiao Qiao;Xiao Huiyu;Li Guang(Department of Radiation Oncology,the First Hospital of China Medical University,Shenyang 110002,China)

机构地区：[1]中国医科大学附属第一医院放射治疗科,沈阳110002

出　　处：《中华放射肿瘤学杂志》2023年第4期370-374,共5页Chinese Journal of Radiation Oncology

摘　　要：对于新诊断胶质母细胞瘤患者,放射治疗后使用肿瘤电场治疗联合替莫唑胺,是目前的标准方案之一。近来,肿瘤电场治疗由于其能够延迟DNA修复和增加DNA复制压力的特性,被越来越多地应用于同步放射治疗,并在一些临床研究中显示出了一定疗效,但关于其理论基础、对放疗剂量的影响、实际临床操作、患者获益、安全性等一直存在争议,缺乏一致性的共识。本文就上述内容的研究进展进行了回顾。For patients with newly diagnosed glioblastoma,tumor treating fields(TTF)combined with temozolomide after radiation therapy is currently one of the standard therapeutic regimens.Recently,TTF has been increasingly applied in combination with radiation therapy since it can delay tumor DNA repair and increase DNA replication stress.The efficacy of TTF has been proven in clinical studies.However,no consensus has been reached regarding the theoretical basis,radiation dose,actual clinical operation,patients'benefit and safety,which remain controversial.In this article,research progress on these topics was reviewed.

关 键 词：胶质母细胞瘤 肿瘤/电场治疗 放射疗法 同步联合治疗 

分 类 号：R739.41[医药卫生—肿瘤]