超高剂量率放疗氧消耗假说的研究进展  

Research progress on the oxygen depletion hypothesis of ultra-high dose rate radiotherapy

作　　者：朱红玉 张奇贤 邓小武[1] Zhu Hongyu;Zhang Qixian;Deng Xiaowu(Department of Radiation Oncology,Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Guangzhou 510060,China;Department of Radiation Oncology,Fudan University Shanghai Cancer Center,Shanghai 200030,China)

机构地区：[1]中山大学肿瘤防治中心放疗科,华南肿瘤学国家重点实验室,广州510060 [2]复旦大学附属肿瘤医院放疗科,上海200030

出　　处：《中华放射肿瘤学杂志》2023年第4期379-383,共5页Chinese Journal of Radiation Oncology

基　　金：国家重点研发计划(2022YFC2402300);国家自然科学基金(12005316);广州市科技计划项目(202201011076)。

摘　　要：超高剂量率(FLASH)放疗是近年来肿瘤放射治疗领域最前沿的研究方向之一。实验表明,FLASH放疗能在保持与临床常规剂量率放疗同等肿瘤控制率的同时,显著减少正常组织中的放射损伤。氧消耗反应被认为是FLASH效应的关键机制之一。本文梳理了氧消耗反应的发现、实验证据及反应原理,总结了其测量手段和生物效应建模方法的研究进展,还讨论了正常组织与肿瘤氧消耗的差异性。In recent years,ultra-high dose rate(FLASH)radiotherapy has become one of the most advanced research topics in the field of radiotherapy.Experimental data indicate that FLASH radiotherapy can significantly reduce the irradiation damage in normal tissues while being as effective as clinical conventional dose rate radiotherapy in tumor control.The oxygen depletion hypothesis is considered as one of the key mechanisms underlying the FLASH effect.In this article,research progress on the discovery,experimental evidence and reaction principle of oxygen depletion was reviewed,the measurement methods and biological effect modeling methods of the oxygen depletion hypothesis were summarized,and the oxygen depletion difference between normal tissue and tumor was also discussed.

关 键 词：放射疗法 超高剂量率 放射生物效应 氧消耗 

分 类 号：R730.55[医药卫生—肿瘤]