肿瘤相关成纤维细胞来源及其在膀胱癌中的研究进展  

Research progress in tumor-associated fibroblast origin and its role in bladder cancer

作　　者：谭智勇 付什 黄应龙[1] 王海峰 王剑松[1] Tan Zhiyong;Fu Shi;Huang Yinglong;Wang Haifeng;Wang Jiansong(Department of Urology,Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院泌尿外科,昆明650101

出　　处：《中华实验外科杂志》2023年第2期387-390,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(81972395、82160583);云南省教育厅科研基金项目(2022Y221);昆明医科大学博士研究生创新基金(2022B25)。

摘　　要：膀胱癌(BC)是最常的泌尿系恶性肿瘤之一,早期诊断和治疗对改善患者预后有着重要意义,手术、放化疗和免疫治疗是BC的主要治疗方式。由于BC具有明显的异质性,导致患者的疗效往往不尽如人意。肿瘤相关成纤维细胞(CAFs)作为肿瘤微环境中非常重要的一类细胞群,通过分泌多种可溶性因子参与肿瘤微环境的调控,在BC的发展中起着关键作用。随着研究的不断深入,CAFs与BC之间的相互作用以及其促进BC发展的具体机制取得了一定的进展,靶向CAFs有望为BC治疗提供新策略,本文就CAFs来源、特征及其在BC中的研究进展进行综述。Bladder cancer(BC)is one of the most common urological malignancies.Early diagnosis and treatment are crucial to improving patient prognosis.Surgery,radiotherapy and immunotherapy are the main treatment modalities for BC.The significant heterogeneity of BC contributes to the unsatisfactory prognosis of patients.Cancer-associated fibroblasts(CAFs),as an important group of cells in the tumor microenvironment,play a key role in the development of BC by secreting a variety of soluble factors to regulate the tumor microenvironment.As research progresses,the interactions between CAFs and BC as well as the specific mechanisms by which they promote the development of BC have made some progress.Targeting CAFs is expected to provide new strategies for BC treatment.This paper reviews the sources and characteristics of CAFs and their research progress in BC.

关 键 词：膀胱癌 肿瘤微环境 肿瘤相关成纤维细胞 

分 类 号：R737.14[医药卫生—肿瘤]