摩罗丹致药物性肝损伤1例  

One case of drug-induced liver injury caused by Morodan

作　　者：高悦[1] 张艳丽[1] Yue GAO;Yan-Li ZHANG(Department of Pharmacy,Shanghai Songjiang District Central Hospital,Shanghai 201600,China)

机构地区：[1]上海市松江区中心医院药剂科,上海201600

出　　处：《药物流行病学杂志》2023年第3期356-360,共5页Chinese Journal of Pharmacoepidemiology

基　　金：2018年上海市临床药学重点专科建设项目[沪卫计药政(2018)9号]。

摘　　要：患者,女,60岁,因慢性萎缩性胃炎予摩罗丹(16丸,po,tid)、奥美拉唑(20 mg,po,bid)等药物治疗后出现乏力、纳差、厌油腻、皮肤巩膜黄染、尿黄等症状,肝功能指标显著升高,丙氨酸氨基转移酶(ALT)1483 U·L^(-1),天冬氨酸氨基转移酶(AST)1066 U·L^(-1),碱性磷酸酶(AKP)351 U·L^(-1),γ-谷氨酰转肽酶(γ-GT)246 U·L^(-1),总胆红素(TBil)28.4μmol·L^(-1),直接胆红素(DBil)24.9μmol·L^(-1)。患者用药前肝功能正常,既往有摩罗丹导致肝功能损伤的病史,根据药物性肝损伤的Roussel Uclaf因果关系评估法,得分9分,考虑“极可能”是摩罗丹导致的药物性肝损伤,予停用摩罗丹并给予保肝治疗,肝功能恢复正常,随访半年,肝功能指标未见异常。A 60-year-old female patient with chronic atrophic gastritis was treated with Morodan(16 pills,po,tid),omeprazole(20 mg,po,bid)and other drugs.After treatment,she developed symptoms such as fatigue,anorexia,greasy,yellow skin and sclera,and yellow urine.The liver function index was significantly increased,ALT 1483 U·L^(-1),AST 1066 U·L^(-1),AKP 351 U·L^(-1),γ-GT 246 U·L^(-1),TBil 28.4μmol·L^(-1),DBil 24.9μmol·L^(-1).The patient’s liver function was normal before medication,and she had a history of liver function damage caused by Morodan.According to the Roussel Uclaf causality assessment method of drug-induced liver injury,the score was 9 points.It was considered that‘most likely’was the drug-induced liver injury caused by Morodan.The liver function returned to normal after discontinuation of Morodan and liver protection treatment.Followed up for half a year,liver function indicators were normal.

关 键 词：摩罗丹 药物性肝损伤 药品不良反应 

分 类 号：R575[医药卫生—消化系统]