基于两样本孟德尔随机化的克罗恩病与胰腺癌发病的因果关系研究  

The causal association between Crohn’s disease and the risk of pancreatic cancer based on two-sample Mendelian randomization

作　　者：赵思亮 罗强 何杰[3] 刘倩 张川 汪汉 ZHAO Si-liang;LUO Qiang;HE Jie;LIU Qian;ZHANG Chuan;WANG Han(Department of Endocrinology and Rheumatology Immunology,The Second People’s Hospital of Jintang county,Chengdu,Sichuan 610404,China;不详)

机构地区：[1]金堂县第二人民医院心血管内分泌科,四川成都610404 [2]西南交通大学附属医院成都市第三人民医院心内科,四川成都610031 [3]金堂县第二人民医院心血管内分泌科

出　　处：《现代预防医学》2023年第7期1333-1338,1344,共7页Modern Preventive Medicine

基　　金：国家自然科学基金(81300243);省科技厅面上项目(19YYJ C0580);四川省中医药管理局项目(2020034)。

摘　　要：目的本文通过两样本孟德尔随机化的方法探究克罗恩病与胰腺癌发病之间的因果关系。方法从全基因组关联分析研究数据中筛出与胰腺癌相关的单核苷酸多态性作为基因工具变量,用逆方差加权分析方法、加权中值方法和MR-Egger方法三种孟德尔随机化方法研究克罗恩病与胰腺癌发病的因果关联。比值比和95%可信区间作结果,OR值评价克罗恩病与胰腺癌发病的因果关系。结果筛选到80个相关SNPs。逆方差加权分析法显示克罗恩病是胰腺癌发病的危险因素(OR=1.106;95%CI:1.009~1.213;P<0.05),MR-Egger效应估计值(OR=1.328;95%CI:1.042~1.693;P<0.05)的统计结果与之类似;加权中值法(OR=1.140;95%CI:0.996~1.305;P>0.05)的统计结果无统计学意义。敏感性分析显示研究结果没有产生偏倚,异质性检验表明SNPs不存在异质性。结论克罗恩病与胰腺癌发病存在正向因果关联。加强克罗恩患者胰腺癌相关的筛查、预防对降低克罗恩患者发生胰腺癌的风险具有重要意义。Objective To investigate the causal relationship between Crohn’s disease and pancreatic cancer using two sample Mendelian randomization.Methods Single nucleotide polymorphisms associated with pancreatic cancer were screened out from the genome-wide association analysis research data as instrumental variables,and the causal association between Crohn’s disease and pancreatic cancer was investigated by three Mendelian randomization methods,including inverse variance weighted analysis,weighted median method,and MR-Egger method.Odds ratio and 95%confidence interval were used to evaluate the causal relationship between Crohn’s disease and pancreatic cancer.Results A total of 80 SNPs were selected as instrumental variable.The inverse variance weighted analysis showed that Crohn’s disease was a risk factor of pancreatic cancer(OR=1.106,95%CI:1.009-1.213,P<0.05),and MR-Egger method derived similar estimation(OR=1.328,95%CI:1.042-1.693,P<0.05).Weighted median method,however,did not confirm the results(OR=1.140,95%CI:0.996-1.305,P>0.05).Sensitivity analysis results indicated the robustness of this study.The heterogeneity test showed that there was no heterogeneity among SNPs.Conclusion There is a positive causal relationship between Crohn’s disease and pancreatic cancer.Strengthening screening and prevention related to pancreatic cancer in Crohn’s patients is of great significance to reduce the risk of pancreatic cancer in Crohn’s patients.

关 键 词：克罗恩病 胰腺癌 孟德尔随机化 因果关系 

分 类 号：R574.62[医药卫生—消化系统] R735.9[医药卫生—内科学]