Hp根除治疗慢性胃炎患者的效果及与hs-CRP的相关性  

Effect of Hp Eradication Therapy in Patients With Chronic Gastritis and its Association With hs-CRP

作　　者：游元明 罗邓成 陈文芳 YOU Yuanming;LUO Dengcheng;CHEN Wenfang(Department of Internal Medicine,Jian'ou Municipal Hospital,Jian'ou Fujian 353100,China)

机构地区：[1]福建省建瓯市立医院内科,福建建瓯353100

出　　处：《中国卫生标准管理》2023年第7期178-181,共4页China Health Standard Management

摘　　要：目的探讨幽门螺杆菌(H.pylori,Hp)根除治疗对慢性胃炎患者肠道菌群的影响及其与血清超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)水平的相关性。方法选择2019年9月—2021年9月于福建省建瓯市立医院内科收治的慢性胃炎患者中50例作为研究对象,均予以Hp根除治疗,药物包括枸橼酸铋钾胶囊、雷贝拉唑钠肠溶胶囊、克拉霉素片、阿莫西林克拉维酸钾片,对其治疗有效率和Hp根除率进行评估,比较治疗前后患者的症状积分、各类菌群数量和血清hs-CRP水平变化,同时对其治疗后肠道菌群数量与血清hs-CRP水平的相关性。结果治疗总有效率和Hp根除率均超过90.00%;治疗后的肠道肠球菌、葡萄球菌数量较治疗前高,肠杆菌、乳杆菌、双歧杆菌数量和血清hs-CRP水平则较治疗前低(P<0.05);各类菌群和患者血清hs-CRP水平无相关(P>0.05)。结论采取Hp根除治疗慢性胃炎,可以有效改善患者症状,提高Hp根除率,促进血清hs-CRP水平下降,但会打破患者肠道菌群平衡,而肠道菌群数量与血清hs-CRP水平无相关,需临床制定更加合理有效的用药方案来保护其肠道菌群,提高整体用药安全性。Objective To investigate the effect of H.pylori(Hp)eradication therapy on intestinal flora in its association with serum hypersensitivity C-reactive protein(hypersensitive C-reactive protein,hs-CRP)levels in patients with chronic gastritis.Methods A total of 50 patients with chronic gastritis admitted to the internal medicine department of Jian'ou Municipal Hospital of Fujian Province from September 2019 to September 2021 were selected as observation objects,all of the patients received Hp eradication therapy,Drugs include bismuth citrate potassium capsules,rabeprazole sodium enteric capsules,clarithromycin tablets,amoxicillin-clavulanate potassium tablets,To evaluate the treatment efficiency and the Hp eradication rate after their treatment,Comparing the changes in symptom integral,number of various flora and serum hs-CRP levels before and after treatment,And the correlation between the number of intestinal microbiota and serum hs-CRP levels after their treatment.Results The total response rate and Hp eradication rate exceeded 90.00%;the number of enterococci and staphylococcus were higher than those after treatment,while the number of enterobacteria,Lactobacillus,bifidobacteria,and serum hs-CRP levels were lower than those before treatment(P<0.05);comparing the association between the flora and patient serum hs-CRP levels,they were unrelated(P>0.05).Conclusion The eradication of Hp in the treatment of chronic gastritis can effectively improve the symptoms of patients and increase the level of H The eradication effect and treatment efficiency of pylori can promote the decrease of serum hs-CRP level,but it will break the balance of intestinal flora of patients.However,the number of intestinal flora is not related to the serum hs-CRP level.Therefore,more reasonable and effective drug regimen should be developed in clinical practice to protect their intestinal flora and improve the overall drug safety.

关 键 词：幽门螺杆菌根除治疗 慢性胃炎 肠道菌群 症状积分 治疗有效率 血清hs-CRP相关性 

分 类 号：R573[医药卫生—消化系统]