尤瑞克林联合血塞通治疗脑栓塞的效果及对血液流变学的影响  

Effectiveness of Urinary Kallindinogenase Combined with Xuesaitong in the Treatment of Cerebral Embolism and the Influence on Blood Rheology

作　　者：陈大龙[1] 魁永健 黄广为 许丽华[1] CHEN Dalong;KUI Yongjian;HUANG Guangwei;XU Lihua(Jiamusi Central Hospital,Heilongjiang Province,Jiamusi 154002,China;不详)

机构地区：[1]黑龙江省佳木斯市中心医院,黑龙江佳木斯154002

出　　处：《中国医学创新》2023年第12期17-21,共5页Medical Innovation of China

摘　　要：目的:探讨尤瑞克林联合血塞通治疗脑栓塞的效果及对血液流变学的影响。方法:选取2020年9月-2022年7月佳木斯市中心医院收治的90例脑栓塞患者,使用随机数字表法将其分为观察组和对照组,各45例。对照组接受血塞通治疗,观察组接受尤瑞克林联合血塞通治疗,对比两组治疗总有效率、血流动力学指标、颈动脉内膜中层厚度及颈动脉斑块面积、炎症因子指标、神经功能缺损评分、日常生活能力评分。结果:观察组治疗总有效率(95.56%)高于对照组(82.22%),差异有统计学意义(P<0.05)。治疗前,两组纤维蛋白原(FIB)、红细胞压积(HCT)、血小板凝集指数、血浆黏度(PV)、颈动脉内膜中层厚度、颈动脉斑块面积、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、可溶性细胞间黏附分子-1(sICAM-1)、白细胞介素-6(IL-6)比较,差异均无统计学意义(P>0.05);治疗后,两组各项指标均降低,观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组美国国立卫生研究院卒中量表(NIHSS)评分及日常生活活动能力量表(ADL)评分差异均无统计学意义(P>0.05);治疗后,两组的NIHSS评分均降低,观察组低于对照组,ADL评分均升高,观察组高于对照组,差异均有统计学意义(P<0.05)。结论:尤瑞克林联合血塞通可有效改善脑栓塞患者的机体血液流变学指标,缩小颈动脉内膜中层厚度及斑块面积,缓解炎症反应,减轻神经功能缺损,提高日常生活能力,效果优异。Objective:To investigate the effect of Urinary Kallindinogenase combined with Xuesaitong in the treatment of cerebral embolism and the influence on blood rheology.Method:Ninety patients with cerebral embolism admitted to Jiamusi Central Hospital from September 2020 to July 2022 were selected and divided into the observation group and the control group using the random number table method,with 45 cases each.The control group received Xuesaitong treatment and the observation group received Urinary Kallindinogenase combined with Xuesaitong treatment.The total effective rate of treatment,hemodynamic indexes,carotid intima-media thickness and carotid plaque area,inflammatory factor indexes,neurological deficit score and daily living ability score were compared between the two groups.Result:The total effective rate of treatment in the observation group(95.56%)was higher than that in the control group(82.22%),the difference was statistically significant(P<0.05).Before treatment,fibrinogen(FIB),hematocrit(HCT),platelet agglutination index,plasma viscosity(PV),carotid intimamedia thickness,carotid plaque area,hypersensitive C reactive protein(hs-CRP),tumour necrosis factor-α(TNF-α),soluble intercellular adhesion molecule-1(sICAM-1)and interleukin-6(IL-6)in both groups were not statistically significant(P>0.05);after treatment,all indicators were reduced in both groups,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the national institutes of health stroke scale(NIHSS)score and activity of daily living scale(ADL)score between the two groups(P>0.05).After treatment,the NIHSS scores of two groups decreased,and that of the observation group was higher than that of the control group,and the ADL scores of two groups increased,that of the observation group was higher than that of the control group,the differences were statistically significant(P<0.05).Conclusion:Urinary Kallindinogenase

关 键 词：脑栓塞 尤瑞克林 血塞通 血液流变学 炎症反应 神经功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]