环丙沙星联合茯苓皮汤加减治疗结直肠癌术后感染临床观察  

Clinical Observation on Ciprofloxacin Combined with Modified Fulingpi Decoction in the Treatment of Postoperative Infection for Colorectal Cancer

作　　者：阿地力江·阿力甫 卡哈尔·吐尔逊 克力比努尔·阿布力米提 阿布都艾尼·阿布都瓦依提 Adilijiang·alifu;Kahaer·Tuerxun;Kelibinuer·Abulimiti;Abuduaini·Abuduwayiti(The First People's Hospital of Kashgar Prefecture,Kashgar 844000,China)

机构地区：[1]喀什地区第一人民医院,新疆喀什844000

出　　处：《西部中医药》2023年第4期101-104,共4页Western Journal of Traditional Chinese Medicine

基　　金：新疆维吾尔自治区自然科学基金(2017D01C019)。

摘　　要：目的:观察环丙沙星联合茯苓皮汤加减治疗结直肠癌术后感染的临床疗效及对胃肠功能、Th1/Th2、C反应蛋白(c reactive protein,CRP)水平的影响。方法:选取结直肠癌术后感染患者92例,依据简单随机数字表法分为观察组与对照组,每组46例。对照组以环丙沙星治疗,观察组在此基础上服用茯苓皮汤加减方,两组均治疗1周。统计两组治疗效果,胃肠功能恢复时间及住院时间,治疗前后Th1/Th2水平,血清炎性因子[降钙素原(procalcitonin,PCT)、CRP、肿瘤坏死因子α(tumor necrosis factor α,TNF-α)、白细胞介素6(interleukin-6,IL-6)]水平,免疫功能指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))水平,不良反应发生率。结果:观察组总有效率[97.83%(45/46)]、不良反应发生率[10.87%(5/46)]与对照组总有效率[93.47%(43/46)]及不良反应发生率[8.70%(4/46)]比较,差异均无统计学意义(P>0.05)。观察组肠鸣音恢复时间、肛门排气时间、首次排便时间、恢复全流饮食时间及住院时间短于对照组(P<0.05)。治疗后两组血清Th1、Th1/Th2、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平较治疗前增高,血清Th2、PCT、CRP、TNF-α、IL-6水平较治疗前降低(P<0.05),且观察组上述指标改善程度优于对照组(P<0.05)。结论:以环丙沙星联合茯苓皮汤加减治疗结直肠癌术后感染效果显著,可促使胃肠功能恢复,提高整体疗效,可能与其能有效调节Th1/Th2、免疫功能及体内炎性反应程度具有一定关联性,且该联合治疗方案安全性具有保证。Objective:To observe clinical effects of ciprofloxacin and modified Fulingpi decoction in the treatment of postoperative infection for colorectal cancer,and its influence on gastrointestinal function,the levels of Th1/Th2 and CRP.Methods:All 92 patients with postoperative infection for colorectal cancer were chosen,allocated to the observation group and the control group according to simple random number table method,with 46 cases in each group.The control group was treated by ciprofloxacin,and the observation group took modified Fulingpi decoction based on ciprofloxacin,both groups were treated for one week.To count therapeutic effects,the recovery time of gastrointestinal function,hospitalization time,the levels of Th1/Th2 before and after treatment,serum inflammatory factors[PCT,CRP,TNF-α,IL-6],the changes of immune function index(CD3^(+),CD4^(+),CD4^(+)/CD8^(+)),and the incidence of adverse reaction between both groups.Results:The difference had no statistical meaning when total effective rate[97.83%(45/46)]and the incidences of adverse reaction[10.87%(5/46)]of the observation group were compared with these[93.47%(43/46)]and[8.70%(4/46)]of the control group(P>0.05).The observation group was shorter than the control group in the recovery time of intestinal gurgling sound,anal exhaust time,first defecation time,the recovery time of liquid diet and length of stay(P<0.05).After the treatment,the levels of Th1,Th1/Th2,CD3^(+),CD4^(+),CD4^(+)/CD8^(+)of both groups increased than before the treatment,the levels of Th2,PCT,CRP,TNF-αand IL-6 reduced than before the treatment(P<0.05),and the improvements of the indexes above of the observation group were superior to these of the control group(P<0.05).Conclusion:Ciprofloxacin and modified Fulingpi decoction are effective in the treatment of postoperative infection for colorectal cancer,which could promote the recovery of gastrointestinal function,raise overall clinical effects,possibly related to effectively regulating Th1/Th2,immune function and degree of inflammator

关 键 词：结直肠癌 环丙沙星 茯苓皮汤 术后感染 胃肠功能 TH1/TH2 C反应蛋白 

分 类 号：R735.35[医药卫生—肿瘤]